Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | ykfI-yeeU/CbtA-CbeA |
| Location | 4613541..4614267 | Replicon | chromosome |
| Accession | NZ_CP100308 | ||
| Organism | Klebsiella pneumoniae strain 1021 | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | - |
| Locus tag | NKY02_RS22590 | Protein ID | WP_107357767.1 |
| Coordinates | 4613541..4613882 (-) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | NKY02_RS22595 | Protein ID | WP_107357768.1 |
| Coordinates | 4613917..4614267 (-) | Length | 117 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NKY02_RS22560 (4608559) | 4608559..4608825 | + | 267 | WP_004178415.1 | hypothetical protein | - |
| NKY02_RS22565 (4608825) | 4608825..4609497 | + | 673 | Protein_4422 | DUF4400 domain-containing protein | - |
| NKY02_RS22570 (4609508) | 4609508..4610392 | + | 885 | WP_004192285.1 | RES domain-containing protein | - |
| NKY02_RS22575 (4610591) | 4610591..4610779 | - | 189 | Protein_4424 | transposase | - |
| NKY02_RS22580 (4610796) | 4610796..4611907 | - | 1112 | Protein_4425 | IS3 family transposase | - |
| NKY02_RS22585 (4612275) | 4612275..4613282 | - | 1008 | WP_107357766.1 | restriction endonuclease | - |
| NKY02_RS22590 (4613541) | 4613541..4613882 | - | 342 | WP_107357767.1 | TA system toxin CbtA family protein | Toxin |
| NKY02_RS22595 (4613917) | 4613917..4614267 | - | 351 | WP_107357768.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| NKY02_RS22600 (4614288) | 4614288..4614509 | - | 222 | WP_107357769.1 | DUF987 domain-containing protein | - |
| NKY02_RS22605 (4614525) | 4614525..4614998 | - | 474 | WP_107357770.1 | DNA repair protein RadC | - |
| NKY02_RS22610 (4615069) | 4615069..4615890 | - | 822 | WP_032437350.1 | DUF932 domain-containing protein | - |
| NKY02_RS22615 (4615986) | 4615986..4616663 | - | 678 | WP_107357771.1 | hypothetical protein | - |
| NKY02_RS22620 (4616948) | 4616948..4617841 | - | 894 | WP_107357772.1 | 50S ribosome-binding GTPase | - |
| NKY02_RS22625 (4617940) | 4617940..4619037 | - | 1098 | WP_117031494.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4602670..4642256 | 39586 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12929.02 Da Isoelectric Point: 10.0932
>T250416 WP_107357767.1 NZ_CP100308:c4613882-4613541 [Klebsiella pneumoniae]
MNTLPAINQRAVQTCLSPVVVWQMLLARLLEQHYGLTLNDTPFSDEAVIKRHIEAGITLVDAVNFLLEKYGLVRIDRRGF
DWQEQSPYLRAVDILRARQATGLLKRNRISAAR
MNTLPAINQRAVQTCLSPVVVWQMLLARLLEQHYGLTLNDTPFSDEAVIKRHIEAGITLVDAVNFLLEKYGLVRIDRRGF
DWQEQSPYLRAVDILRARQATGLLKRNRISAAR
Download Length: 342 bp
Antitoxin
Download Length: 117 a.a. Molecular weight: 12974.90 Da Isoelectric Point: 6.6206
>AT250416 WP_107357768.1 NZ_CP100308:c4614267-4613917 [Klebsiella pneumoniae]
MSNKTLTVNDDTAEPWWGLSRNVIPCFGARLVQEGNRLHYLAGRASLTGQIHEADLLHLDQAFPVLLKQMELMLTCGELN
PRHQHCVTLYAKGLTCEADTLGSCGYVYIAIYPTQR
MSNKTLTVNDDTAEPWWGLSRNVIPCFGARLVQEGNRLHYLAGRASLTGQIHEADLLHLDQAFPVLLKQMELMLTCGELN
PRHQHCVTLYAKGLTCEADTLGSCGYVYIAIYPTQR
Download Length: 351 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|