Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2660347..2661935 Replicon chromosome
Accession NZ_CP100308
Organism Klebsiella pneumoniae strain 1021

Toxin (Protein)


Gene name hipA Uniprot ID A0A486KW17
Locus tag NKY02_RS13075 Protein ID WP_004190166.1
Coordinates 2660347..2661669 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NKY02_RS13080 Protein ID WP_002904790.1
Coordinates 2661669..2661935 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NKY02_RS13060 (2655403) 2655403..2657904 + 2502 WP_004190161.1 fimbria/pilus outer membrane usher protein -
NKY02_RS13065 (2657892) 2657892..2658896 + 1005 WP_004190163.1 fimbrial protein -
NKY02_RS13070 (2659038) 2659038..2660330 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NKY02_RS13075 (2660347) 2660347..2661669 - 1323 WP_004190166.1 type II toxin-antitoxin system HipA family toxin Toxin
NKY02_RS13080 (2661669) 2661669..2661935 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NKY02_RS13085 (2662200) 2662200..2662526 - 327 WP_004143476.1 hydroxyisourate hydrolase -
NKY02_RS13090 (2662523) 2662523..2663023 - 501 WP_004190169.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NKY02_RS13095 (2663001) 2663001..2664380 - 1380 WP_259699833.1 nucleobase:cation symporter-2 family protein -
NKY02_RS13100 (2664726) 2664726..2665880 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NKY02_RS13105 (2665861) 2665861..2666784 - 924 WP_004190172.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 2460321..2702478 242157


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T250413 WP_004190166.1 NZ_CP100308:c2661669-2660347 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTTLLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT250413 WP_002904790.1 NZ_CP100308:c2661935-2661669 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486KW17

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References