250404

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 3433..4021 Replicon plasmid unnamed2
Accession NZ_CP100307
Organism Acinetobacter baumannii strain KBN10P05679

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag NIK71_RS19860 Protein ID WP_000438826.1
Coordinates 3433..3720 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag NIK71_RS19865 Protein ID WP_001983304.1
Coordinates 3707..4021 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIK71_RS19840 (NIK71_19840) 672..1622 + 951 WP_001205343.1 replication initiation protein RepM -
NIK71_RS19845 (NIK71_19845) 1615..2190 + 576 WP_001096616.1 plasmid replication DNA-binding protein -
NIK71_RS19850 (NIK71_19850) 2210..2353 + 144 WP_001125246.1 hypothetical protein -
NIK71_RS19855 (NIK71_19855) 2542..3060 - 519 WP_000447193.1 tetratricopeptide repeat protein -
NIK71_RS19860 (NIK71_19860) 3433..3720 + 288 WP_000438826.1 BrnT family toxin Toxin
NIK71_RS19865 (NIK71_19865) 3707..4021 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
NIK71_RS19870 (NIK71_19870) 4149..6560 + 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
NIK71_RS19875 (NIK71_19875) 6865..7326 + 462 WP_000761346.1 DIP1984 family protein -
NIK71_RS19880 (NIK71_19880) 7649..7822 - 174 WP_001282484.1 hypothetical protein -
NIK71_RS19885 (NIK71_19885) 7822..8193 - 372 WP_000504218.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..8731 8731


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T250404 WP_000438826.1 NZ_CP100307:3433-3720 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT250404 WP_001983304.1 NZ_CP100307:3707-4021 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References