Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1971127..1971902 Replicon chromosome
Accession NZ_CP100300
Organism Burkholderia glumae strain BGR81S

Toxin (Protein)


Gene name TacT2 Uniprot ID C5AIF4
Locus tag NIY08_RS08465 Protein ID WP_015877380.1
Coordinates 1971127..1971624 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID C5AIF5
Locus tag NIY08_RS08470 Protein ID WP_015877381.1
Coordinates 1971621..1971902 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY08_RS08430 1967148..1967243 - 96 Protein_1651 IS5/IS1182 family transposase -
NIY08_RS08435 1967315..1967860 - 546 Protein_1652 IS3 family transposase -
NIY08_RS08440 1968053..1968858 + 806 WP_085962370.1 IS5 family transposase -
NIY08_RS08445 1968824..1969135 - 312 WP_015877377.1 hypothetical protein -
NIY08_RS08450 1969152..1969403 - 252 WP_230674552.1 hypothetical protein -
NIY08_RS08455 1969530..1970135 - 606 Protein_1656 RHS repeat-associated core domain-containing protein -
NIY08_RS08460 1970549..1971046 - 498 WP_015877379.1 ProQ/FINO family protein -
NIY08_RS08465 1971127..1971624 - 498 WP_015877380.1 GNAT family N-acetyltransferase Toxin
NIY08_RS08470 1971621..1971902 - 282 WP_015877381.1 DUF1778 domain-containing protein Antitoxin
NIY08_RS08475 1971899..1972276 - 378 WP_173941242.1 hypothetical protein -
NIY08_RS08480 1972359..1972721 - 363 WP_017432434.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fliC 1955593..1998873 43280
- flank IS/Tn - - 1967291..1967833 542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(5-91)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17544.11 Da        Isoelectric Point: 9.6894

>T250396 WP_015877380.1 NZ_CP100300:c1971624-1971127 [Burkholderia glumae]
VTGWRAPEPLSDAHGLDDFDSGVASLDTWLKRRALANQRSGASRTFVATRDGRVGAYYALASGAVTLEVAPGRFRRNMPD
PIPVVVLGRLAVDRAHQGIGVGRALVRDAGLRVLHAAAAIGIRGLIVHALSDSAKAFYERVGFEASPLDPMLLLITLADL
EHALS

Download         Length: 498 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10256.52 Da        Isoelectric Point: 5.0477

>AT250396 WP_015877381.1 NZ_CP100300:c1971902-1971621 [Burkholderia glumae]
MTSTTPRDTLNLRIRPDDRSLIDRAAAAAHKTRTDFVLDAARAAAEQTLLDQVVLSAEPQAYAAFLARLDEPVQPNEALR
QTMQTRAPWDPAA

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9HNC8

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9HNC9

References