Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | slvAT/RES(toxin) |
| Location | 5409..6355 | Replicon | plasmid psl2395s2p |
| Accession | NZ_CP100299 | ||
| Organism | Burkholderia glumae strain SL-2395S | ||
Toxin (Protein)
| Gene name | slvT | Uniprot ID | C5AN91 |
| Locus tag | NIX96_RS31325 | Protein ID | WP_012732709.1 |
| Coordinates | 5822..6355 (+) | Length | 178 a.a. |
Antitoxin (Protein)
| Gene name | slvA | Uniprot ID | C5AN90 |
| Locus tag | NIX96_RS31320 | Protein ID | WP_012732708.1 |
| Coordinates | 5409..5825 (+) | Length | 139 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NIX96_RS31300 | 1342..2421 | + | 1080 | WP_012732706.1 | ParB N-terminal domain-containing protein | - |
| NIX96_RS31305 | 2758..4089 | + | 1332 | WP_012732707.1 | hypothetical protein | - |
| NIX96_RS31310 | 4211..4537 | + | 327 | WP_127913985.1 | hypothetical protein | - |
| NIX96_RS31315 | 5076..5261 | + | 186 | WP_148271081.1 | hypothetical protein | - |
| NIX96_RS31320 | 5409..5825 | + | 417 | WP_012732708.1 | DUF2384 domain-containing protein | Antitoxin |
| NIX96_RS31325 | 5822..6355 | + | 534 | WP_012732709.1 | RES family NAD+ phosphorylase | Toxin |
| NIX96_RS31330 | 6525..6713 | + | 189 | WP_017432455.1 | hypothetical protein | - |
| NIX96_RS31335 | 7334..7618 | + | 285 | WP_017924445.1 | hypothetical protein | - |
| NIX96_RS31340 | 7631..7870 | + | 240 | WP_017924444.1 | hypothetical protein | - |
| NIX96_RS31345 | 7867..8202 | + | 336 | WP_155297056.1 | hypothetical protein | - |
| NIX96_RS31350 | 8199..8540 | + | 342 | WP_039204389.1 | hypothetical protein | - |
| NIX96_RS31355 | 8543..10378 | + | 1836 | WP_039204391.1 | site-specific integrase | - |
| NIX96_RS31360 | 10481..10888 | + | 408 | WP_230674553.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..128912 | 128912 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 178 a.a. Molecular weight: 19101.61 Da Isoelectric Point: 4.7118
>T250395 WP_012732709.1 NZ_CP100299:5822-6355 [Burkholderia glumae]
MILTPLQDITAYRMHVPKWAVAPTSGAGAAKAGGRANRIGTPALYLALEAATAVAEYQQLSPLLPPGTLVSYRVTATPVV
DFTGGYRVDLWPPLWESFFCDWRHDWFNARIEPPSWVLGDEAIASGAKGILFRSTQAAGGTNLVLFVDQLGEGDRVDVHD
PAGALPRDQASWVDSPE
MILTPLQDITAYRMHVPKWAVAPTSGAGAAKAGGRANRIGTPALYLALEAATAVAEYQQLSPLLPPGTLVSYRVTATPVV
DFTGGYRVDLWPPLWESFFCDWRHDWFNARIEPPSWVLGDEAIASGAKGILFRSTQAAGGTNLVLFVDQLGEGDRVDVHD
PAGALPRDQASWVDSPE
Download Length: 534 bp
Antitoxin
Download Length: 139 a.a. Molecular weight: 14709.55 Da Isoelectric Point: 6.4664
>AT250395 WP_012732708.1 NZ_CP100299:5409-5825 [Burkholderia glumae]
MSTLAAARAPAGGPALANFDAFLSALREPDTAAPVLSARRYVAALNIDLQTLADQAHVHRNTVARAPQSASVQQFLREAI
RVIRAATDLSGDVQRALFWYRNEPLAVFDYQTAETLVSAGRADDVVRYVASLEAGAAG
MSTLAAARAPAGGPALANFDAFLSALREPDTAAPVLSARRYVAALNIDLQTLADQAHVHRNTVARAPQSASVQQFLREAI
RVIRAATDLSGDVQRALFWYRNEPLAVFDYQTAETLVSAGRADDVVRYVASLEAGAAG
Download Length: 417 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J9GLU3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J9GLX3 |