Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2902131..2902735 Replicon chromosome
Accession NZ_CP100296
Organism Burkholderia glumae strain SL-2395S

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NIX96_RS13760 Protein ID WP_017922254.1
Coordinates 2902131..2902313 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NIX96_RS13765 Protein ID WP_017922253.1
Coordinates 2902340..2902735 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIX96_RS13730 2897616..2897864 - 249 WP_039201402.1 gpW family head-tail joining protein -
NIX96_RS13735 2897881..2899953 - 2073 WP_257834958.1 phage terminase large subunit family protein -
NIX96_RS13740 2900006..2900710 - 705 WP_251107513.1 hypothetical protein -
NIX96_RS13745 2900760..2901005 - 246 WP_254983853.1 hypothetical protein -
NIX96_RS13750 2901154..2901354 - 201 WP_124837747.1 DUF2591 family protein -
NIX96_RS13755 2901360..2902058 - 699 WP_257818528.1 hypothetical protein -
NIX96_RS13760 2902131..2902313 + 183 WP_017922254.1 type II toxin-antitoxin system HicA family toxin Toxin
NIX96_RS13765 2902340..2902735 + 396 WP_017922253.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NIX96_RS13770 2903032..2903463 - 432 WP_157384052.1 hypothetical protein -
NIX96_RS13775 2903456..2904049 - 594 WP_254983860.1 hypothetical protein -
NIX96_RS13780 2904568..2905410 - 843 WP_257835068.1 toprim domain-containing protein -
NIX96_RS13785 2905397..2906944 - 1548 WP_257835069.1 DEAD/DEAH box helicase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-123)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6599.76 Da        Isoelectric Point: 11.2641

>T250391 WP_017922254.1 NZ_CP100296:2902131-2902313 [Burkholderia glumae]
MNSANLIRTLKADGWYLVNTVGSHHQFKHATKPGKVTVPHPKKDLPLGTVRSILKQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14466.21 Da        Isoelectric Point: 4.5532

>AT250391 WP_017922253.1 NZ_CP100296:2902340-2902735 [Burkholderia glumae]
MLYPLYVHVGDDKHAHGVTFPDFPGCHAAADSWDELPAAVQEAAQAHFEGDDSPIPEPSALEDLTRDPEYTGGVWMIFDI
DLSKINTKAVRFNVSMSERLLQKIDAKARARKLSRSAFLAIAAEHEMEADA

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References