Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 111828..112465 Replicon plasmid pr22p
Accession NZ_CP100294
Organism Burkholderia glumae strain R2

Toxin (Protein)


Gene name vapC Uniprot ID C5AP38
Locus tag NIX97_RS30000 Protein ID WP_012735347.1
Coordinates 111828..112229 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag NIX97_RS30005 Protein ID WP_017924531.1
Coordinates 112229..112465 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIX97_RS29970 108741..109469 - 729 WP_257804669.1 IS6 family transposase -
NIX97_RS29975 109510..109869 + 360 Protein_110 OB-fold nucleic acid binding domain-containing protein -
NIX97_RS29980 109882..110169 + 288 WP_176359098.1 hypothetical protein -
NIX97_RS29985 110435..110629 - 195 WP_124837731.1 hypothetical protein -
NIX97_RS29990 110990..111232 - 243 WP_039205039.1 hypothetical protein -
NIX97_RS29995 111250..111579 - 330 WP_155297075.1 hypothetical protein -
NIX97_RS30000 111828..112229 - 402 WP_012735347.1 type II toxin-antitoxin system VapC family toxin Toxin
NIX97_RS30005 112229..112465 - 237 WP_017924531.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NIX97_RS30010 113024..114528 - 1505 Protein_117 IS21 family transposase -
NIX97_RS30015 114620..116371 - 1752 WP_257804676.1 S8 family peptidase -
NIX97_RS30020 116381..117364 - 984 WP_012732876.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..152564 152564
- inside IScluster/Tn - - 106963..113941 6978


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-117)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14847.12 Da        Isoelectric Point: 5.2138

>T250389 WP_012735347.1 NZ_CP100294:c112229-111828 [Burkholderia glumae]
MPRFMLDTNMCIYLMKNQPEQVAKRFAECFVGDVVMSAITYAELEYGVAVSDNRAKERRNLAALIEDILVAPFDAAAAVA
YGPIREATRERKKDHLDKLIAAHAVALDVVLVTNNAKDFASYPGIKLDNWLND

Download         Length: 402 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8965.10 Da        Isoelectric Point: 6.3676

>AT250389 WP_017924531.1 NZ_CP100294:c112465-112229 [Burkholderia glumae]
MQTTRVFRNGNSQAVRIPADLAYERSDVELEIERVGDEIRIRPARRPLTGVLKKFAKFSQDFMAEGRGEQEQAEREGL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C5AP38

Antitoxin

Source ID Structure

References