Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2508836..2509440 Replicon chromosome
Accession NZ_CP100291
Organism Burkholderia glumae strain R2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NIX97_RS11725 Protein ID WP_017922254.1
Coordinates 2508836..2509018 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NIX97_RS11730 Protein ID WP_017922253.1
Coordinates 2509045..2509440 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIX97_RS11695 2504321..2504569 - 249 WP_039201402.1 gpW family head-tail joining protein -
NIX97_RS11700 2504586..2506658 - 2073 WP_257756915.1 phage terminase large subunit family protein -
NIX97_RS11705 2506711..2507415 - 705 WP_251107513.1 hypothetical protein -
NIX97_RS11710 2507465..2507710 - 246 WP_039201374.1 hypothetical protein -
NIX97_RS11715 2507697..2508059 - 363 WP_039201376.1 DUF2591 family protein -
NIX97_RS11720 2508065..2508685 - 621 WP_039201377.1 hypothetical protein -
NIX97_RS11725 2508836..2509018 + 183 WP_017922254.1 type II toxin-antitoxin system HicA family toxin Toxin
NIX97_RS11730 2509045..2509440 + 396 WP_017922253.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NIX97_RS11735 2509882..2510115 + 234 WP_257803289.1 hypothetical protein -
NIX97_RS11740 2511201..2511632 - 432 WP_257744544.1 hypothetical protein -
NIX97_RS11745 2511625..2512218 - 594 WP_257803290.1 hypothetical protein -
NIX97_RS11750 2512737..2513579 - 843 WP_257803291.1 toprim domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2480404..2524393 43989


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-123)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6599.76 Da        Isoelectric Point: 11.2641

>T250385 WP_017922254.1 NZ_CP100291:2508836-2509018 [Burkholderia glumae]
MNSANLIRTLKADGWYLVNTVGSHHQFKHATKPGKVTVPHPKKDLPLGTVRSILKQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14466.21 Da        Isoelectric Point: 4.5532

>AT250385 WP_017922253.1 NZ_CP100291:2509045-2509440 [Burkholderia glumae]
MLYPLYVHVGDDKHAHGVTFPDFPGCHAAADSWDELPAAVQEAAQAHFEGDDSPIPEPSALEDLTRDPEYTGGVWMIFDI
DLSKINTKAVRFNVSMSERLLQKIDAKARARKLSRSAFLAIAAEHEMEADA

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References