Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | slvAT/RES(toxin) |
| Location | 5409..6355 | Replicon | plasmid p48s3p |
| Accession | NZ_CP100289 | ||
| Organism | Burkholderia glumae strain BGR48S | ||
Toxin (Protein)
| Gene name | slvT | Uniprot ID | C5AN91 |
| Locus tag | NIX85_RS29795 | Protein ID | WP_012732709.1 |
| Coordinates | 5822..6355 (+) | Length | 178 a.a. |
Antitoxin (Protein)
| Gene name | slvA | Uniprot ID | C5AN90 |
| Locus tag | NIX85_RS29790 | Protein ID | WP_012732708.1 |
| Coordinates | 5409..5825 (+) | Length | 139 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NIX85_RS29765 | 535..1338 | + | 804 | WP_257777563.1 | AAA family ATPase | - |
| NIX85_RS29770 | 1341..2420 | + | 1080 | WP_012732706.1 | ParB N-terminal domain-containing protein | - |
| NIX85_RS29775 | 2757..4088 | + | 1332 | WP_257820536.1 | helix-turn-helix domain-containing protein | - |
| NIX85_RS29780 | 4210..4536 | + | 327 | WP_127913985.1 | hypothetical protein | - |
| NIX85_RS29785 | 5076..5261 | + | 186 | WP_017432454.1 | hypothetical protein | - |
| NIX85_RS29790 | 5409..5825 | + | 417 | WP_012732708.1 | DUF2384 domain-containing protein | Antitoxin |
| NIX85_RS29795 | 5822..6355 | + | 534 | WP_012732709.1 | RES family NAD+ phosphorylase | Toxin |
| NIX85_RS29800 | 6525..6713 | + | 189 | WP_017432455.1 | hypothetical protein | - |
| NIX85_RS29805 | 7339..7554 | + | 216 | WP_161522034.1 | hypothetical protein | - |
| NIX85_RS29810 | 7746..7919 | + | 174 | WP_161522033.1 | hypothetical protein | - |
| NIX85_RS29815 | 7932..8171 | + | 240 | WP_161522032.1 | hypothetical protein | - |
| NIX85_RS29820 | 8267..8503 | + | 237 | WP_161522031.1 | hypothetical protein | - |
| NIX85_RS29825 | 8500..8841 | + | 342 | WP_176359138.1 | hypothetical protein | - |
| NIX85_RS29830 | 8844..10680 | + | 1837 | Protein_14 | site-specific integrase | - |
| NIX85_RS29835 | 10743..11189 | + | 447 | WP_257820546.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..112798 | 112798 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 178 a.a. Molecular weight: 19101.61 Da Isoelectric Point: 4.7118
>T250381 WP_012732709.1 NZ_CP100289:5822-6355 [Burkholderia glumae]
MILTPLQDITAYRMHVPKWAVAPTSGAGAAKAGGRANRIGTPALYLALEAATAVAEYQQLSPLLPPGTLVSYRVTATPVV
DFTGGYRVDLWPPLWESFFCDWRHDWFNARIEPPSWVLGDEAIASGAKGILFRSTQAAGGTNLVLFVDQLGEGDRVDVHD
PAGALPRDQASWVDSPE
MILTPLQDITAYRMHVPKWAVAPTSGAGAAKAGGRANRIGTPALYLALEAATAVAEYQQLSPLLPPGTLVSYRVTATPVV
DFTGGYRVDLWPPLWESFFCDWRHDWFNARIEPPSWVLGDEAIASGAKGILFRSTQAAGGTNLVLFVDQLGEGDRVDVHD
PAGALPRDQASWVDSPE
Download Length: 534 bp
Antitoxin
Download Length: 139 a.a. Molecular weight: 14709.55 Da Isoelectric Point: 6.4664
>AT250381 WP_012732708.1 NZ_CP100289:5409-5825 [Burkholderia glumae]
MSTLAAARAPAGGPALANFDAFLSALREPDTAAPVLSARRYVAALNIDLQTLADQAHVHRNTVARAPQSASVQQFLREAI
RVIRAATDLSGDVQRALFWYRNEPLAVFDYQTAETLVSAGRADDVVRYVASLEAGAAG
MSTLAAARAPAGGPALANFDAFLSALREPDTAAPVLSARRYVAALNIDLQTLADQAHVHRNTVARAPQSASVQQFLREAI
RVIRAATDLSGDVQRALFWYRNEPLAVFDYQTAETLVSAGRADDVVRYVASLEAGAAG
Download Length: 417 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J9GLU3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J9GLX3 |