Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1093490..1094265 Replicon chromosome
Accession NZ_CP100286
Organism Burkholderia glumae strain BGR48S

Toxin (Protein)


Gene name TacT2 Uniprot ID C5AIF4
Locus tag NIX85_RS21475 Protein ID WP_015877380.1
Coordinates 1093768..1094265 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID C5AIF5
Locus tag NIX85_RS21470 Protein ID WP_015877381.1
Coordinates 1093490..1093771 (+) Length 94 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIX85_RS21445 1089435..1090301 - 867 WP_012732871.1 IS21-like element ISBcen28 family helper ATPase IstB -
NIX85_RS21450 1090298..1091554 - 1257 WP_257818908.1 IS21 family transposase -
NIX85_RS21455 1091679..1092662 + 984 Protein_933 RHS repeat-associated core domain-containing protein -
NIX85_RS21460 1092671..1093033 + 363 WP_017432434.1 hypothetical protein -
NIX85_RS21465 1093116..1093493 + 378 WP_173941242.1 hypothetical protein -
NIX85_RS21470 1093490..1093771 + 282 WP_015877381.1 DUF1778 domain-containing protein Antitoxin
NIX85_RS21475 1093768..1094265 + 498 WP_015877380.1 GNAT family N-acetyltransferase Toxin
NIX85_RS21480 1094346..1094843 + 498 WP_015877379.1 ProQ/FINO family protein -
NIX85_RS21485 1095247..1096064 + 818 WP_085962362.1 IS5-like element ISBugl2 family transposase -
NIX85_RS21490 1096189..1097208 + 1020 WP_252836473.1 IS110 family transposase -
NIX85_RS21495 1098298..1099101 + 804 WP_257819546.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1072169..1099101 26932
- inside IScluster/Tn - - 1089435..1097208 7773


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(44-144)

Antitoxin

(5-91)


Sequences


Toxin        


Download         Length: 166 a.a.        Molecular weight: 17544.11 Da        Isoelectric Point: 9.6894

>T250379 WP_015877380.1 NZ_CP100286:1093768-1094265 [Burkholderia glumae]
VTGWRAPEPLSDAHGLDDFDSGVASLDTWLKRRALANQRSGASRTFVATRDGRVGAYYALASGAVTLEVAPGRFRRNMPD
PIPVVVLGRLAVDRAHQGIGVGRALVRDAGLRVLHAAAAIGIRGLIVHALSDSAKAFYERVGFEASPLDPMLLLITLADL
EHALS

Download         Length: 498 bp


Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10256.52 Da        Isoelectric Point: 5.0477

>AT250379 WP_015877381.1 NZ_CP100286:1093490-1093771 [Burkholderia glumae]
MTSTTPRDTLNLRIRPDDRSLIDRAAAAAHKTRTDFVLDAARAAAEQTLLDQVVLSAEPQAYAAFLARLDEPVQPNEALR
QTMQTRAPWDPAA

Download         Length: 282 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2J9HNC8


Antitoxin

Source ID Structure
AlphaFold DB A0A2J9HNC9

References