Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 50874..51820 Replicon plasmid pyh82p
Accession NZ_CP100283
Organism Burkholderia glumae strain YH8

Toxin (Protein)


Gene name slvT Uniprot ID C5AN91
Locus tag NIY09_RS31005 Protein ID WP_012732709.1
Coordinates 51287..51820 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID C5AN90
Locus tag NIY09_RS31000 Protein ID WP_012732708.1
Coordinates 50874..51290 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY09_RS30980 46806..47885 + 1080 WP_012732706.1 ParB N-terminal domain-containing protein -
NIY09_RS30985 48222..49553 + 1332 WP_012732707.1 hypothetical protein -
NIY09_RS30990 49675..50001 + 327 WP_127913985.1 hypothetical protein -
NIY09_RS30995 50541..50726 + 186 WP_017432454.1 hypothetical protein -
NIY09_RS31000 50874..51290 + 417 WP_012732708.1 DUF2384 domain-containing protein Antitoxin
NIY09_RS31005 51287..51820 + 534 WP_012732709.1 RES family NAD+ phosphorylase Toxin
NIY09_RS31010 51990..52178 + 189 WP_017432455.1 hypothetical protein -
NIY09_RS31015 52930..53214 + 285 WP_017432347.1 hypothetical protein -
NIY09_RS31020 53228..53470 + 243 WP_124837682.1 hypothetical protein -
NIY09_RS31025 53467..53712 + 246 WP_127913916.1 hypothetical protein -
NIY09_RS31030 53769..54110 + 342 WP_012732710.1 hypothetical protein -
NIY09_RS31035 54113..55948 + 1836 WP_012732711.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..139256 139256
- flank IS/Tn - - 56237..56566 329


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(11-168)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19101.61 Da        Isoelectric Point: 4.7118

>T250377 WP_012732709.1 NZ_CP100283:51287-51820 [Burkholderia glumae]
MILTPLQDITAYRMHVPKWAVAPTSGAGAAKAGGRANRIGTPALYLALEAATAVAEYQQLSPLLPPGTLVSYRVTATPVV
DFTGGYRVDLWPPLWESFFCDWRHDWFNARIEPPSWVLGDEAIASGAKGILFRSTQAAGGTNLVLFVDQLGEGDRVDVHD
PAGALPRDQASWVDSPE

Download         Length: 534 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14709.55 Da        Isoelectric Point: 6.4664

>AT250377 WP_012732708.1 NZ_CP100283:50874-51290 [Burkholderia glumae]
MSTLAAARAPAGGPALANFDAFLSALREPDTAAPVLSARRYVAALNIDLQTLADQAHVHRNTVARAPQSASVQQFLREAI
RVIRAATDLSGDVQRALFWYRNEPLAVFDYQTAETLVSAGRADDVVRYVASLEAGAAG

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9GLU3

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9GLX3

References