Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 60032..60627 Replicon plasmid pyh81p
Accession NZ_CP100282
Organism Burkholderia glumae strain YH8

Toxin (Protein)


Gene name chpB Uniprot ID C5AN78
Locus tag NIY09_RS30270 Protein ID WP_012734107.1
Coordinates 60277..60627 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID C5AN79
Locus tag NIY09_RS30265 Protein ID WP_012734108.1
Coordinates 60032..60283 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY09_RS30225 55080..55349 + 270 WP_012732894.1 DUF1778 domain-containing protein -
NIY09_RS30230 55346..55834 + 489 WP_012732893.1 GNAT family N-acetyltransferase -
NIY09_RS30235 56241..56525 + 285 WP_017432347.1 hypothetical protein -
NIY09_RS30240 56539..56781 + 243 WP_124837682.1 hypothetical protein -
NIY09_RS30245 56778..57023 + 246 WP_127913916.1 hypothetical protein -
NIY09_RS30250 57080..57421 + 342 WP_012732710.1 hypothetical protein -
NIY09_RS30255 57424..59259 + 1836 WP_012732711.1 site-specific integrase -
NIY09_RS30260 59362..59769 + 408 WP_230674618.1 hypothetical protein -
NIY09_RS30265 60032..60283 + 252 WP_012734108.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NIY09_RS30270 60277..60627 + 351 WP_012734107.1 type II toxin-antitoxin system ChpB family toxin Toxin
NIY09_RS30275 60686..60880 + 195 WP_124837685.1 hypothetical protein -
NIY09_RS30280 61030..61251 + 222 WP_017433768.1 hypothetical protein -
NIY09_RS30285 61474..61938 + 465 WP_012734106.1 Lrp/AsnC family transcriptional regulator -
NIY09_RS30290 62252..64627 + 2376 WP_232252305.1 TonB-dependent receptor -
NIY09_RS30295 64659..65405 + 747 WP_232252306.1 energy transducer TonB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..147448 147448


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12389.37 Da        Isoelectric Point: 8.8909

>T250376 WP_012734107.1 NZ_CP100282:60277-60627 [Burkholderia glumae]
MVKRVKFERGDIVRVSLSPTVGREQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARFAGFAVPLSGSGTETQGVALV
NMVRMLDLEGRGARKIERAPVEVVEDALARLQTIIE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 8940.31 Da        Isoelectric Point: 6.2420

>AT250376 WP_012734108.1 NZ_CP100282:60032-60283 [Burkholderia glumae]
MELKIQKWGNSAAVRLPSVLLEQINASVGGSLNADVRPDGVLLTPARRKYALDDLVAQCDTKAPVPADMAAWGEIKPVGR
EAW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A246MF70

Antitoxin

Source ID Structure
AlphaFold DB A0A246MFN5

References