Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1714613..1715388 Replicon chromosome
Accession NZ_CP100281
Organism Burkholderia glumae strain YH8

Toxin (Protein)


Gene name TacT2 Uniprot ID C5AIF4
Locus tag NIY09_RS24480 Protein ID WP_015877380.1
Coordinates 1714613..1715110 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID C5AIF5
Locus tag NIY09_RS24485 Protein ID WP_015877381.1
Coordinates 1715107..1715388 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY09_RS24445 1709665..1709976 - 312 WP_015877377.1 hypothetical protein -
NIY09_RS24450 1709993..1710244 - 252 WP_230674552.1 hypothetical protein -
NIY09_RS24455 1710371..1710976 - 606 Protein_1346 RHS repeat-associated core domain-containing protein -
NIY09_RS24460 1711390..1711563 - 174 WP_257806536.1 ProQ/FinO family protein -
NIY09_RS24465 1711679..1713265 - 1587 WP_012732733.1 IS66 family transposase -
NIY09_RS24470 1713365..1713718 - 354 WP_012732734.1 IS66 family insertion sequence element accessory protein TnpB -
NIY09_RS24475 1713718..1714173 - 456 WP_012732735.1 transposase -
NIY09_RS24480 1714613..1715110 - 498 WP_015877380.1 GNAT family N-acetyltransferase Toxin
NIY09_RS24485 1715107..1715388 - 282 WP_015877381.1 DUF1778 domain-containing protein Antitoxin
NIY09_RS24490 1715385..1715762 - 378 WP_173941242.1 hypothetical protein -
NIY09_RS24495 1715845..1716207 - 363 WP_017432434.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fliC 1695477..1743635 48158


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(5-91)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17544.11 Da        Isoelectric Point: 9.6894

>T250374 WP_015877380.1 NZ_CP100281:c1715110-1714613 [Burkholderia glumae]
VTGWRAPEPLSDAHGLDDFDSGVASLDTWLKRRALANQRSGASRTFVATRDGRVGAYYALASGAVTLEVAPGRFRRNMPD
PIPVVVLGRLAVDRAHQGIGVGRALVRDAGLRVLHAAAAIGIRGLIVHALSDSAKAFYERVGFEASPLDPMLLLITLADL
EHALS

Download         Length: 498 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10256.52 Da        Isoelectric Point: 5.0477

>AT250374 WP_015877381.1 NZ_CP100281:c1715388-1715107 [Burkholderia glumae]
MTSTTPRDTLNLRIRPDDRSLIDRAAAAAHKTRTDFVLDAARAAAEQTLLDQVVLSAEPQAYAAFLARLDEPVQPNEALR
QTMQTRAPWDPAA

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9HNC8

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9HNC9

References