Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2294106..2294710 Replicon chromosome
Accession NZ_CP100280
Organism Burkholderia glumae strain YH8

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NIY09_RS10910 Protein ID WP_017922254.1
Coordinates 2294106..2294288 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NIY09_RS10915 Protein ID WP_257827237.1
Coordinates 2294315..2294710 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY09_RS10885 2289590..2289838 - 249 WP_039201402.1 gpW family head-tail joining protein -
NIY09_RS10890 2289855..2291927 - 2073 WP_257827235.1 phage terminase large subunit family protein -
NIY09_RS10895 2291980..2292684 - 705 WP_039201372.1 hypothetical protein -
NIY09_RS10900 2292967..2293329 - 363 WP_039201376.1 DUF2591 family protein -
NIY09_RS10905 2293335..2293955 - 621 WP_039201377.1 hypothetical protein -
NIY09_RS10910 2294106..2294288 + 183 WP_017922254.1 type II toxin-antitoxin system HicA family toxin Toxin
NIY09_RS10915 2294315..2294710 + 396 WP_257827237.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NIY09_RS10920 2295152..2295385 + 234 WP_257803289.1 hypothetical protein -
NIY09_RS10925 2296471..2296902 - 432 WP_039201379.1 hypothetical protein -
NIY09_RS10930 2296895..2297488 - 594 WP_257827239.1 hypothetical protein -
NIY09_RS10935 2297472..2297690 - 219 WP_017922250.1 hypothetical protein -
NIY09_RS10940 2297737..2298246 - 510 WP_257744542.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2262725..2310829 48104


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-123)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6599.76 Da        Isoelectric Point: 11.2641

>T250373 WP_017922254.1 NZ_CP100280:2294106-2294288 [Burkholderia glumae]
MNSANLIRTLKADGWYLVNTVGSHHQFKHATKPGKVTVPHPKKDLPLGTVRSILKQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14436.22 Da        Isoelectric Point: 4.6421

>AT250373 WP_257827237.1 NZ_CP100280:2294315-2294710 [Burkholderia glumae]
MLYPLYVHVGDDKHAHGVTFPDFPGCHAAADSWDELPAAVQEAAQAHFEGDDSPIPVPSALEDLTRDPEYTGGVWMIFDI
DLSKINTKAVRFNVSMSERLLQKIDAKARARKLSRSAFLAIAAEHEMEADA

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References