Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 165563..166140 Replicon plasmid p76s2p
Accession NZ_CP100259
Organism Burkholderia glumae strain BGR76S

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NIX80_RS31320 Protein ID WP_186012873.1
Coordinates 165563..165928 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NIX80_RS31325 Protein ID WP_098183406.1
Coordinates 165922..166140 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIX80_RS31290 160612..161604 + 993 WP_257806835.1 IS5 family transposase -
NIX80_RS31295 161826..162818 + 993 WP_257806835.1 IS5 family transposase -
NIX80_RS31300 163012..163769 + 758 Protein_136 IS5 family transposase -
NIX80_RS31305 163777..164004 - 228 WP_257806837.1 hypothetical protein -
NIX80_RS31310 164069..164755 - 687 WP_257806838.1 hypothetical protein -
NIX80_RS31315 164776..165303 - 528 WP_257806839.1 hypothetical protein -
NIX80_RS31320 165563..165928 - 366 WP_186012873.1 type II toxin-antitoxin system VapC family toxin Toxin
NIX80_RS31325 165922..166140 - 219 WP_098183406.1 ribbon-helix-helix protein, CopG family Antitoxin
NIX80_RS31330 166288..166722 - 435 WP_257806909.1 tyrosine-type recombinase/integrase -
NIX80_RS31335 166989..167981 - 993 WP_257806835.1 IS5 family transposase -
NIX80_RS31340 168089..168886 - 798 WP_257806840.1 IS5 family transposase -
NIX80_RS31345 169020..170012 + 993 WP_257806835.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..177259 177259
- inside IScluster/Tn - - 158561..170012 11451


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-106)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-39)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13386.51 Da        Isoelectric Point: 7.0133

>T250360 WP_186012873.1 NZ_CP100259:c165928-165563 [Burkholderia glumae]
MVKALFDTNILIDYLNGVGAAKKELARYEYRAISVITWMEVLVGASGEEDAAIRAWLDTFDVVAVDSAIANRAVEIRKAK
KIRLPDAIVWASAQVHSVLLVSRNTKDFPADEPGVRVPYKI

Download         Length: 366 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8273.42 Da        Isoelectric Point: 5.0651

>AT250360 WP_098183406.1 NZ_CP100259:c166140-165922 [Burkholderia glumae]
MSRILVDLPESQVDDLAVIVEAEQRPRAAIIRDAIEAYISQRKRALGTDVFGLWKSRKTDGLAYQQELRSEW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References