Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 121647..122284 Replicon plasmid p76s1p
Accession NZ_CP100258
Organism Burkholderia glumae strain BGR76S

Toxin (Protein)


Gene name vapC Uniprot ID C5AP38
Locus tag NIX80_RS29375 Protein ID WP_012735347.1
Coordinates 121647..122048 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID C5AP39
Locus tag NIX80_RS29380 Protein ID WP_012735348.1
Coordinates 122048..122284 (-) Length 79 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIX80_RS29345 118110..118379 + 270 WP_012735343.1 hypothetical protein -
NIX80_RS29350 118539..119153 + 615 Protein_104 error-prone DNA polymerase -
NIX80_RS29355 119169..119456 + 288 WP_012735344.1 hypothetical protein -
NIX80_RS29360 120560..120754 - 195 WP_124837731.1 hypothetical protein -
NIX80_RS29365 120809..121051 - 243 WP_012735345.1 hypothetical protein -
NIX80_RS29370 121069..121632 - 564 WP_012735346.1 hypothetical protein -
NIX80_RS29375 121647..122048 - 402 WP_012735347.1 type II toxin-antitoxin system VapC family toxin Toxin
NIX80_RS29380 122048..122284 - 237 WP_012735348.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NIX80_RS29385 122621..123313 - 693 WP_043308722.1 hypothetical protein -
NIX80_RS29390 123397..125223 - 1827 WP_012735349.1 site-specific integrase -
NIX80_RS29395 125220..125600 - 381 WP_080569442.1 hypothetical protein -
NIX80_RS29400 125603..125920 - 318 WP_050811486.1 hypothetical protein -
NIX80_RS29405 125971..127059 - 1089 Protein_115 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..362586 362586


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-117)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 134 a.a.        Molecular weight: 14847.12 Da        Isoelectric Point: 5.2138

>T250357 WP_012735347.1 NZ_CP100258:c122048-121647 [Burkholderia glumae]
MPRFMLDTNMCIYLMKNQPEQVAKRFAECFVGDVVMSAITYAELEYGVAVSDNRAKERRNLAALIEDILVAPFDAAAAVA
YGPIREATRERKKDHLDKLIAAHAVALDVVLVTNNAKDFASYPGIKLDNWLND

Download         Length: 402 bp


Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8983.13 Da        Isoelectric Point: 6.3676

>AT250357 WP_012735348.1 NZ_CP100258:c122284-122048 [Burkholderia glumae]
MQTTRVFRNGNSQAVRIPADLAYERSDVELEIERVGDEIRIRPARRPLTGVLKKFAKFSQDFMAEGRGEQEQAEREGM

Download         Length: 237 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB C5AP38


Antitoxin

Source ID Structure
AlphaFold DB C5AP39

References