Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1710343..1711118 Replicon chromosome
Accession NZ_CP100257
Organism Burkholderia glumae strain BGR76S

Toxin (Protein)


Gene name TacT2 Uniprot ID C5AIF4
Locus tag NIX80_RS23425 Protein ID WP_015877380.1
Coordinates 1710343..1710840 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID C5AIF5
Locus tag NIX80_RS23430 Protein ID WP_015877381.1
Coordinates 1710837..1711118 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIX80_RS23390 1705395..1705706 - 312 WP_015877377.1 hypothetical protein -
NIX80_RS23395 1705723..1705974 - 252 WP_230674552.1 hypothetical protein -
NIX80_RS23400 1706101..1706706 - 606 Protein_1350 RHS repeat-associated core domain-containing protein -
NIX80_RS23405 1707120..1707293 - 174 WP_257806536.1 ProQ/FinO family protein -
NIX80_RS23410 1707409..1708995 - 1587 WP_012732733.1 IS66 family transposase -
NIX80_RS23415 1709095..1709448 - 354 WP_012732734.1 IS66 family insertion sequence element accessory protein TnpB -
NIX80_RS23420 1709448..1709903 - 456 WP_012732735.1 transposase -
NIX80_RS23425 1710343..1710840 - 498 WP_015877380.1 GNAT family N-acetyltransferase Toxin
NIX80_RS23430 1710837..1711118 - 282 WP_015877381.1 DUF1778 domain-containing protein Antitoxin
NIX80_RS23435 1711115..1711492 - 378 WP_173941242.1 hypothetical protein -
NIX80_RS23440 1711575..1711937 - 363 WP_017432434.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fliC 1691207..1739365 48158


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(5-91)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17544.11 Da        Isoelectric Point: 9.6894

>T250355 WP_015877380.1 NZ_CP100257:c1710840-1710343 [Burkholderia glumae]
VTGWRAPEPLSDAHGLDDFDSGVASLDTWLKRRALANQRSGASRTFVATRDGRVGAYYALASGAVTLEVAPGRFRRNMPD
PIPVVVLGRLAVDRAHQGIGVGRALVRDAGLRVLHAAAAIGIRGLIVHALSDSAKAFYERVGFEASPLDPMLLLITLADL
EHALS

Download         Length: 498 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10256.52 Da        Isoelectric Point: 5.0477

>AT250355 WP_015877381.1 NZ_CP100257:c1711118-1710837 [Burkholderia glumae]
MTSTTPRDTLNLRIRPDDRSLIDRAAAAAHKTRTDFVLDAARAAAEQTLLDQVVLSAEPQAYAAFLARLDEPVQPNEALR
QTMQTRAPWDPAA

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9HNC8

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9HNC9

References