Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1663754..1664529 Replicon chromosome
Accession NZ_CP100245
Organism Burkholderia glumae strain BGR28S

Toxin (Protein)


Gene name TacT2 Uniprot ID C5AIF4
Locus tag NIX71_RS24335 Protein ID WP_015877380.1
Coordinates 1663754..1664251 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID C5AIF5
Locus tag NIX71_RS24340 Protein ID WP_015877381.1
Coordinates 1664248..1664529 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIX71_RS24300 1659775..1659870 - 96 Protein_1306 IS5/IS1182 family transposase -
NIX71_RS24305 1659942..1660487 - 546 Protein_1307 IS3 family transposase -
NIX71_RS24310 1660680..1661485 + 806 WP_085962370.1 IS5 family transposase -
NIX71_RS24315 1661451..1661762 - 312 WP_015877377.1 hypothetical protein -
NIX71_RS24320 1661779..1662030 - 252 WP_230674552.1 hypothetical protein -
NIX71_RS24325 1662157..1662762 - 606 Protein_1311 RHS repeat-associated core domain-containing protein -
NIX71_RS24330 1663176..1663673 - 498 WP_015877379.1 ProQ/FINO family protein -
NIX71_RS24335 1663754..1664251 - 498 WP_015877380.1 GNAT family N-acetyltransferase Toxin
NIX71_RS24340 1664248..1664529 - 282 WP_015877381.1 DUF1778 domain-containing protein Antitoxin
NIX71_RS24345 1664526..1664903 - 378 WP_173941242.1 hypothetical protein -
NIX71_RS24350 1664986..1665348 - 363 WP_017432434.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fliC 1647761..1690077 42316
- flank IS/Tn - - 1659918..1660460 542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(5-91)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17544.11 Da        Isoelectric Point: 9.6894

>T250347 WP_015877380.1 NZ_CP100245:c1664251-1663754 [Burkholderia glumae]
VTGWRAPEPLSDAHGLDDFDSGVASLDTWLKRRALANQRSGASRTFVATRDGRVGAYYALASGAVTLEVAPGRFRRNMPD
PIPVVVLGRLAVDRAHQGIGVGRALVRDAGLRVLHAAAAIGIRGLIVHALSDSAKAFYERVGFEASPLDPMLLLITLADL
EHALS

Download         Length: 498 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10256.52 Da        Isoelectric Point: 5.0477

>AT250347 WP_015877381.1 NZ_CP100245:c1664529-1664248 [Burkholderia glumae]
MTSTTPRDTLNLRIRPDDRSLIDRAAAAAHKTRTDFVLDAARAAAEQTLLDQVVLSAEPQAYAAFLARLDEPVQPNEALR
QTMQTRAPWDPAA

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9HNC8

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9HNC9

References