Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1705797..1706572 Replicon chromosome
Accession NZ_CP100239
Organism Burkholderia glumae strain BGR22S

Toxin (Protein)


Gene name TacT2 Uniprot ID C5AIF4
Locus tag NIX74_RS24795 Protein ID WP_015877380.1
Coordinates 1705797..1706294 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID C5AIF5
Locus tag NIX74_RS24800 Protein ID WP_015877381.1
Coordinates 1706291..1706572 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIX74_RS24760 1701818..1701913 - 96 Protein_1345 IS5/IS1182 family transposase -
NIX74_RS24765 1701985..1702530 - 546 Protein_1346 IS3 family transposase -
NIX74_RS24770 1702723..1703528 + 806 WP_085962370.1 IS5 family transposase -
NIX74_RS24775 1703494..1703805 - 312 WP_015877377.1 hypothetical protein -
NIX74_RS24780 1703822..1704124 - 303 WP_255220127.1 DUF2380 domain-containing protein -
NIX74_RS24785 1704200..1704805 - 606 Protein_1350 RHS repeat-associated core domain-containing protein -
NIX74_RS24790 1705219..1705716 - 498 WP_015877379.1 ProQ/FINO family protein -
NIX74_RS24795 1705797..1706294 - 498 WP_015877380.1 GNAT family N-acetyltransferase Toxin
NIX74_RS24800 1706291..1706572 - 282 WP_015877381.1 DUF1778 domain-containing protein Antitoxin
NIX74_RS24805 1706569..1706946 - 378 WP_173941242.1 hypothetical protein -
NIX74_RS24810 1707029..1707391 - 363 WP_017432434.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fliC 1688887..1732119 43232
- flank IS/Tn - - 1701961..1702503 542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(5-91)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17544.11 Da        Isoelectric Point: 9.6894

>T250343 WP_015877380.1 NZ_CP100239:c1706294-1705797 [Burkholderia glumae]
VTGWRAPEPLSDAHGLDDFDSGVASLDTWLKRRALANQRSGASRTFVATRDGRVGAYYALASGAVTLEVAPGRFRRNMPD
PIPVVVLGRLAVDRAHQGIGVGRALVRDAGLRVLHAAAAIGIRGLIVHALSDSAKAFYERVGFEASPLDPMLLLITLADL
EHALS

Download         Length: 498 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10256.52 Da        Isoelectric Point: 5.0477

>AT250343 WP_015877381.1 NZ_CP100239:c1706572-1706291 [Burkholderia glumae]
MTSTTPRDTLNLRIRPDDRSLIDRAAAAAHKTRTDFVLDAARAAAEQTLLDQVVLSAEPQAYAAFLARLDEPVQPNEALR
QTMQTRAPWDPAA

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9HNC8

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9HNC9

References