Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 336363..337036 Replicon plasmid pPAT9B01
Accession NC_014838
Organism Pantoea sp. At-9b

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag PAT9B_RS21940 Protein ID WP_083810354.1
Coordinates 336363..336761 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PAT9B_RS21945 Protein ID WP_013511473.1
Coordinates 336782..337036 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAT9B_RS21910 332536..332691 + 156 WP_013511466.1 type I toxin-antitoxin system Hok family toxin -
PAT9B_RS21915 332768..333397 - 630 WP_013511467.1 DUF1109 family protein -
PAT9B_RS21920 333390..333941 - 552 WP_013511468.1 sigma-70 family RNA polymerase sigma factor -
PAT9B_RS21925 333958..335190 - 1233 WP_013511469.1 thioredoxin family protein -
PAT9B_RS21930 335206..335775 - 570 WP_013511470.1 peroxiredoxin -
PAT9B_RS21935 336042..336320 + 279 Protein_349 hypothetical protein -
PAT9B_RS21940 336363..336761 - 399 WP_083810354.1 HipA domain-containing protein Toxin
PAT9B_RS21945 336782..337036 - 255 WP_013511473.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
PAT9B_RS21950 337297..337752 + 456 WP_013511474.1 acetyl-CoA carboxylase biotin carboxyl carrier protein -
PAT9B_RS21955 337764..339113 + 1350 WP_013511475.1 acetyl-CoA carboxylase biotin carboxylase subunit -
PAT9B_RS21960 339129..340400 + 1272 WP_013511476.1 Glu/Leu/Phe/Val dehydrogenase -
PAT9B_RS21965 340510..341589 - 1080 WP_013511477.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN 1..793953 793953


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(3-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14988.53 Da        Isoelectric Point: 10.3341

>T25034 WP_083810354.1 NC_014838:c336761-336363 [Pantoea sp. At-9b]
MNGATDGHAKNFSVFIERGGSYRLTPFYDVISAYPVLGGTGLNIRDLKLAMGLKATKGKKMEIEKIFPRHFMATAKAVNF
DQNRMVEIMDFFITQFPDAIRQVERMLPADFPPRIADVLFSQSLRMLARLQQ

Download         Length: 399 bp

>T25034 NC_014838:c336761-336363 [Pantoea sp. At-9b]
ATGAATGGTGCCACCGACGGACATGCGAAAAACTTCTCGGTATTTATTGAGCGAGGGGGCAGCTATCGCCTGACACCTTT
CTATGATGTCATTTCGGCTTACCCCGTGTTGGGTGGAACCGGATTGAACATCCGTGATCTGAAACTGGCGATGGGGTTAA
AAGCCACGAAAGGTAAAAAGATGGAGATTGAGAAAATATTCCCACGGCATTTTATGGCAACGGCTAAGGCAGTAAATTTT
GACCAGAACCGCATGGTGGAAATTATGGATTTCTTTATTACGCAATTCCCAGACGCCATCCGCCAAGTAGAACGTATGTT
ACCCGCTGATTTCCCGCCCCGTATCGCCGATGTACTGTTTTCCCAAAGCCTGCGAATGCTGGCGCGTTTACAGCAATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9840.20 Da        Isoelectric Point: 7.4013

>AT25034 WP_013511473.1 NC_014838:c337036-336782 [Pantoea sp. At-9b]
MIYSPRQLAHHIRLIRQKNQWTQTQLAKKVGLKQATISHFENNPDLTTLATLFKILQSLELKLDIHEKLDANETPASYDQ
ENDW

Download         Length: 255 bp

>AT25034 NC_014838:c337036-336782 [Pantoea sp. At-9b]
ATGATTTATAGCCCAAGACAGCTTGCTCATCACATCCGGTTAATTCGACAGAAAAATCAGTGGACCCAGACGCAACTCGC
CAAAAAAGTGGGGCTGAAACAGGCCACGATCTCACATTTCGAAAACAATCCCGACCTGACCACCCTGGCGACGCTGTTTA
AGATCCTGCAGTCCCTTGAACTAAAGCTGGATATTCACGAGAAGCTGGACGCAAACGAGACTCCGGCGAGTTACGATCAG
GAGAATGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References