Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1719141..1719916 Replicon chromosome
Accession NZ_CP100234
Organism Burkholderia glumae strain BGR19S

Toxin (Protein)


Gene name TacT2 Uniprot ID C5AIF4
Locus tag NIX15_RS24180 Protein ID WP_015877380.1
Coordinates 1719141..1719638 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID C5AIF5
Locus tag NIX15_RS24185 Protein ID WP_015877381.1
Coordinates 1719635..1719916 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIX15_RS24145 1714595..1715944 + 1350 WP_015877376.1 allantoin permease -
NIX15_RS24150 1716030..1716125 - 96 Protein_1365 IS5/IS1182 family transposase -
NIX15_RS24155 1716197..1716742 - 546 Protein_1366 IS3 family transposase -
NIX15_RS24160 1716865..1717149 - 285 WP_153478924.1 hypothetical protein -
NIX15_RS24165 1717166..1717468 - 303 WP_255220127.1 DUF2380 domain-containing protein -
NIX15_RS24170 1717544..1718149 - 606 Protein_1369 RHS repeat-associated core domain-containing protein -
NIX15_RS24175 1718563..1719060 - 498 WP_015877379.1 ProQ/FINO family protein -
NIX15_RS24180 1719141..1719638 - 498 WP_015877380.1 GNAT family N-acetyltransferase Toxin
NIX15_RS24185 1719635..1719916 - 282 WP_015877381.1 DUF1778 domain-containing protein Antitoxin
NIX15_RS24190 1719913..1720290 - 378 WP_173941242.1 hypothetical protein -
NIX15_RS24195 1720373..1720735 - 363 WP_017432434.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(5-91)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17544.11 Da        Isoelectric Point: 9.6894

>T250339 WP_015877380.1 NZ_CP100234:c1719638-1719141 [Burkholderia glumae]
VTGWRAPEPLSDAHGLDDFDSGVASLDTWLKRRALANQRSGASRTFVATRDGRVGAYYALASGAVTLEVAPGRFRRNMPD
PIPVVVLGRLAVDRAHQGIGVGRALVRDAGLRVLHAAAAIGIRGLIVHALSDSAKAFYERVGFEASPLDPMLLLITLADL
EHALS

Download         Length: 498 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10256.52 Da        Isoelectric Point: 5.0477

>AT250339 WP_015877381.1 NZ_CP100234:c1719916-1719635 [Burkholderia glumae]
MTSTTPRDTLNLRIRPDDRSLIDRAAAAAHKTRTDFVLDAARAAAEQTLLDQVVLSAEPQAYAAFLARLDEPVQPNEALR
QTMQTRAPWDPAA

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9HNC8

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9HNC9

References