Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1739840..1740615 Replicon chromosome
Accession NZ_CP100204
Organism Burkholderia glumae strain PW30RS

Toxin (Protein)


Gene name TacT2 Uniprot ID C5AIF4
Locus tag NIW90_RS25730 Protein ID WP_015877380.1
Coordinates 1739840..1740337 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID C5AIF5
Locus tag NIW90_RS25735 Protein ID WP_015877381.1
Coordinates 1740334..1740615 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIW90_RS25695 1735861..1735956 - 96 Protein_1387 IS5/IS1182 family transposase -
NIW90_RS25700 1736028..1736573 - 546 Protein_1388 IS3 family transposase -
NIW90_RS25705 1736766..1737571 + 806 WP_085962370.1 IS5 family transposase -
NIW90_RS25710 1737537..1737848 - 312 WP_015877377.1 hypothetical protein -
NIW90_RS25715 1737865..1738167 - 303 WP_255220127.1 DUF2380 domain-containing protein -
NIW90_RS25720 1738243..1738848 - 606 Protein_1392 RHS repeat-associated core domain-containing protein -
NIW90_RS25725 1739262..1739759 - 498 WP_015877379.1 ProQ/FINO family protein -
NIW90_RS25730 1739840..1740337 - 498 WP_015877380.1 GNAT family N-acetyltransferase Toxin
NIW90_RS25735 1740334..1740615 - 282 WP_015877381.1 DUF1778 domain-containing protein Antitoxin
NIW90_RS25740 1740612..1740989 - 378 WP_173941242.1 hypothetical protein -
NIW90_RS25745 1741072..1741434 - 363 WP_017432434.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fliC 1723847..1766163 42316
- flank IS/Tn - - 1736004..1736546 542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(5-91)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17544.11 Da        Isoelectric Point: 9.6894

>T250319 WP_015877380.1 NZ_CP100204:c1740337-1739840 [Burkholderia glumae]
VTGWRAPEPLSDAHGLDDFDSGVASLDTWLKRRALANQRSGASRTFVATRDGRVGAYYALASGAVTLEVAPGRFRRNMPD
PIPVVVLGRLAVDRAHQGIGVGRALVRDAGLRVLHAAAAIGIRGLIVHALSDSAKAFYERVGFEASPLDPMLLLITLADL
EHALS

Download         Length: 498 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10256.52 Da        Isoelectric Point: 5.0477

>AT250319 WP_015877381.1 NZ_CP100204:c1740615-1740334 [Burkholderia glumae]
MTSTTPRDTLNLRIRPDDRSLIDRAAAAAHKTRTDFVLDAARAAAEQTLLDQVVLSAEPQAYAAFLARLDEPVQPNEALR
QTMQTRAPWDPAA

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9HNC8

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9HNC9

References