Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 11254..11849 Replicon plasmid p947s2p
Accession NZ_CP100189
Organism Burkholderia glumae strain SL-947S

Toxin (Protein)


Gene name chpB Uniprot ID C5AN78
Locus tag NIW76_RS29970 Protein ID WP_012734107.1
Coordinates 11499..11849 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID C5AN79
Locus tag NIW76_RS29965 Protein ID WP_012734108.1
Coordinates 11254..11505 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIW76_RS29930 6523..6711 + 189 WP_017432455.1 hypothetical protein -
NIW76_RS29935 7463..7747 + 285 WP_017432347.1 hypothetical protein -
NIW76_RS29940 7761..8003 + 243 WP_124837682.1 hypothetical protein -
NIW76_RS29945 8000..8245 + 246 WP_127913916.1 hypothetical protein -
NIW76_RS29950 8302..8643 + 342 WP_012732710.1 hypothetical protein -
NIW76_RS29955 8646..10481 + 1836 WP_012732711.1 site-specific integrase -
NIW76_RS29960 10584..10991 + 408 WP_230674618.1 hypothetical protein -
NIW76_RS29965 11254..11505 + 252 WP_012734108.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NIW76_RS29970 11499..11849 + 351 WP_012734107.1 type II toxin-antitoxin system ChpB family toxin Toxin
NIW76_RS29975 11908..12102 + 195 WP_124837685.1 hypothetical protein -
NIW76_RS29980 12252..12473 + 222 WP_017433768.1 hypothetical protein -
NIW76_RS29985 12695..13159 + 465 WP_012734106.1 Lrp/AsnC family transcriptional regulator -
NIW76_RS29990 13473..15848 + 2376 WP_232252305.1 TonB-dependent receptor -
NIW76_RS29995 15880..16626 + 747 WP_232252306.1 energy transducer TonB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..128913 128913


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12389.37 Da        Isoelectric Point: 8.8909

>T250310 WP_012734107.1 NZ_CP100189:11499-11849 [Burkholderia glumae]
MVKRVKFERGDIVRVSLSPTVGREQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARFAGFAVPLSGSGTETQGVALV
NMVRMLDLEGRGARKIERAPVEVVEDALARLQTIIE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 8940.31 Da        Isoelectric Point: 6.2420

>AT250310 WP_012734108.1 NZ_CP100189:11254-11505 [Burkholderia glumae]
MELKIQKWGNSAAVRLPSVLLEQINASVGGSLNADVRPDGVLLTPARRKYALDDLVAQCDTKAPVPADMAAWGEIKPVGR
EAW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A246MF70

Antitoxin

Source ID Structure
AlphaFold DB A0A246MFN5

References