Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | slvAT/RES(toxin) |
| Location | 5407..6353 | Replicon | plasmid p947s2p |
| Accession | NZ_CP100189 | ||
| Organism | Burkholderia glumae strain SL-947S | ||
Toxin (Protein)
| Gene name | slvT | Uniprot ID | C5AN91 |
| Locus tag | NIW76_RS29925 | Protein ID | WP_012732709.1 |
| Coordinates | 5820..6353 (+) | Length | 178 a.a. |
Antitoxin (Protein)
| Gene name | slvA | Uniprot ID | C5AN90 |
| Locus tag | NIW76_RS29920 | Protein ID | WP_012732708.1 |
| Coordinates | 5407..5823 (+) | Length | 139 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NIW76_RS29890 | 534..1337 | + | 804 | WP_257777563.1 | AAA family ATPase | - |
| NIW76_RS29895 | 1340..2419 | + | 1080 | WP_012732706.1 | ParB N-terminal domain-containing protein | - |
| NIW76_RS29900 | 2756..3460 | + | 705 | WP_257803199.1 | helix-turn-helix domain-containing protein | - |
| NIW76_RS29905 | 3496..4086 | + | 591 | WP_257803200.1 | hypothetical protein | - |
| NIW76_RS29910 | 4208..4534 | + | 327 | WP_127913985.1 | hypothetical protein | - |
| NIW76_RS29915 | 5074..5259 | + | 186 | WP_017432454.1 | hypothetical protein | - |
| NIW76_RS29920 | 5407..5823 | + | 417 | WP_012732708.1 | DUF2384 domain-containing protein | Antitoxin |
| NIW76_RS29925 | 5820..6353 | + | 534 | WP_012732709.1 | RES family NAD+ phosphorylase | Toxin |
| NIW76_RS29930 | 6523..6711 | + | 189 | WP_017432455.1 | hypothetical protein | - |
| NIW76_RS29935 | 7463..7747 | + | 285 | WP_017432347.1 | hypothetical protein | - |
| NIW76_RS29940 | 7761..8003 | + | 243 | WP_124837682.1 | hypothetical protein | - |
| NIW76_RS29945 | 8000..8245 | + | 246 | WP_127913916.1 | hypothetical protein | - |
| NIW76_RS29950 | 8302..8643 | + | 342 | WP_012732710.1 | hypothetical protein | - |
| NIW76_RS29955 | 8646..10481 | + | 1836 | WP_012732711.1 | site-specific integrase | - |
| NIW76_RS29960 | 10584..10991 | + | 408 | WP_230674618.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..128913 | 128913 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 178 a.a. Molecular weight: 19101.61 Da Isoelectric Point: 4.7118
>T250309 WP_012732709.1 NZ_CP100189:5820-6353 [Burkholderia glumae]
MILTPLQDITAYRMHVPKWAVAPTSGAGAAKAGGRANRIGTPALYLALEAATAVAEYQQLSPLLPPGTLVSYRVTATPVV
DFTGGYRVDLWPPLWESFFCDWRHDWFNARIEPPSWVLGDEAIASGAKGILFRSTQAAGGTNLVLFVDQLGEGDRVDVHD
PAGALPRDQASWVDSPE
MILTPLQDITAYRMHVPKWAVAPTSGAGAAKAGGRANRIGTPALYLALEAATAVAEYQQLSPLLPPGTLVSYRVTATPVV
DFTGGYRVDLWPPLWESFFCDWRHDWFNARIEPPSWVLGDEAIASGAKGILFRSTQAAGGTNLVLFVDQLGEGDRVDVHD
PAGALPRDQASWVDSPE
Download Length: 534 bp
Antitoxin
Download Length: 139 a.a. Molecular weight: 14709.55 Da Isoelectric Point: 6.4664
>AT250309 WP_012732708.1 NZ_CP100189:5407-5823 [Burkholderia glumae]
MSTLAAARAPAGGPALANFDAFLSALREPDTAAPVLSARRYVAALNIDLQTLADQAHVHRNTVARAPQSASVQQFLREAI
RVIRAATDLSGDVQRALFWYRNEPLAVFDYQTAETLVSAGRADDVVRYVASLEAGAAG
MSTLAAARAPAGGPALANFDAFLSALREPDTAAPVLSARRYVAALNIDLQTLADQAHVHRNTVARAPQSASVQQFLREAI
RVIRAATDLSGDVQRALFWYRNEPLAVFDYQTAETLVSAGRADDVVRYVASLEAGAAG
Download Length: 417 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J9GLU3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J9GLX3 |