Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1690915..1691690 Replicon chromosome
Accession NZ_CP100187
Organism Burkholderia glumae strain SL-947S

Toxin (Protein)


Gene name TacT2 Uniprot ID C5AIF4
Locus tag NIW76_RS24060 Protein ID WP_015877380.1
Coordinates 1690915..1691412 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID C5AIF5
Locus tag NIW76_RS24065 Protein ID WP_015877381.1
Coordinates 1691409..1691690 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIW76_RS24025 1686936..1687031 - 96 Protein_1327 IS5/IS1182 family transposase -
NIW76_RS24030 1687103..1687648 - 546 Protein_1328 IS3 family transposase -
NIW76_RS24035 1687841..1688646 + 806 WP_085962370.1 IS5 family transposase -
NIW76_RS24040 1688612..1688923 - 312 WP_015877377.1 hypothetical protein -
NIW76_RS24045 1688940..1689191 - 252 WP_230674552.1 hypothetical protein -
NIW76_RS24050 1689318..1689923 - 606 Protein_1332 RHS repeat-associated core domain-containing protein -
NIW76_RS24055 1690337..1690834 - 498 WP_015877379.1 ProQ/FINO family protein -
NIW76_RS24060 1690915..1691412 - 498 WP_015877380.1 GNAT family N-acetyltransferase Toxin
NIW76_RS24065 1691409..1691690 - 282 WP_015877381.1 DUF1778 domain-containing protein Antitoxin
NIW76_RS24070 1691687..1692064 - 378 WP_173941242.1 hypothetical protein -
NIW76_RS24075 1692147..1692509 - 363 WP_017432434.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fliC 1676805..1712888 36083
- flank IS/Tn - - 1687079..1687621 542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(5-91)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17544.11 Da        Isoelectric Point: 9.6894

>T250308 WP_015877380.1 NZ_CP100187:c1691412-1690915 [Burkholderia glumae]
VTGWRAPEPLSDAHGLDDFDSGVASLDTWLKRRALANQRSGASRTFVATRDGRVGAYYALASGAVTLEVAPGRFRRNMPD
PIPVVVLGRLAVDRAHQGIGVGRALVRDAGLRVLHAAAAIGIRGLIVHALSDSAKAFYERVGFEASPLDPMLLLITLADL
EHALS

Download         Length: 498 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10256.52 Da        Isoelectric Point: 5.0477

>AT250308 WP_015877381.1 NZ_CP100187:c1691690-1691409 [Burkholderia glumae]
MTSTTPRDTLNLRIRPDDRSLIDRAAAAAHKTRTDFVLDAARAAAEQTLLDQVVLSAEPQAYAAFLARLDEPVQPNEALR
QTMQTRAPWDPAA

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9HNC8

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9HNC9

References