Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1704551..1705326 Replicon chromosome
Accession NZ_CP100182
Organism Burkholderia glumae strain R5

Toxin (Protein)


Gene name TacT2 Uniprot ID C5AIF4
Locus tag NIW68_RS23970 Protein ID WP_015877380.1
Coordinates 1704551..1705048 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID C5AIF5
Locus tag NIW68_RS23975 Protein ID WP_015877381.1
Coordinates 1705045..1705326 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIW68_RS23935 1700572..1700667 - 96 Protein_1346 IS5/IS1182 family transposase -
NIW68_RS23940 1700739..1701284 - 546 Protein_1347 IS3 family transposase -
NIW68_RS23945 1701477..1702282 + 806 WP_085962370.1 IS5 family transposase -
NIW68_RS23950 1702248..1702559 - 312 WP_015877377.1 hypothetical protein -
NIW68_RS23955 1702576..1702878 - 303 WP_255220127.1 DUF2380 domain-containing protein -
NIW68_RS23960 1702954..1703559 - 606 Protein_1351 RHS repeat-associated core domain-containing protein -
NIW68_RS23965 1703973..1704470 - 498 WP_015877379.1 ProQ/FINO family protein -
NIW68_RS23970 1704551..1705048 - 498 WP_015877380.1 GNAT family N-acetyltransferase Toxin
NIW68_RS23975 1705045..1705326 - 282 WP_015877381.1 DUF1778 domain-containing protein Antitoxin
NIW68_RS23980 1705323..1705700 - 378 WP_173941242.1 hypothetical protein -
NIW68_RS23985 1705783..1706145 - 363 WP_017432434.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fliC 1688558..1730874 42316
- flank IS/Tn - - 1700715..1701257 542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(5-91)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17544.11 Da        Isoelectric Point: 9.6894

>T250300 WP_015877380.1 NZ_CP100182:c1705048-1704551 [Burkholderia glumae]
VTGWRAPEPLSDAHGLDDFDSGVASLDTWLKRRALANQRSGASRTFVATRDGRVGAYYALASGAVTLEVAPGRFRRNMPD
PIPVVVLGRLAVDRAHQGIGVGRALVRDAGLRVLHAAAAIGIRGLIVHALSDSAKAFYERVGFEASPLDPMLLLITLADL
EHALS

Download         Length: 498 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10256.52 Da        Isoelectric Point: 5.0477

>AT250300 WP_015877381.1 NZ_CP100182:c1705326-1705045 [Burkholderia glumae]
MTSTTPRDTLNLRIRPDDRSLIDRAAAAAHKTRTDFVLDAARAAAEQTLLDQVVLSAEPQAYAAFLARLDEPVQPNEALR
QTMQTRAPWDPAA

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9HNC8

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9HNC9

References