Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1705376..1706151 Replicon chromosome
Accession NZ_CP100175
Organism Burkholderia glumae strain BGR86S

Toxin (Protein)


Gene name TacT2 Uniprot ID C5AIF4
Locus tag NIW65_RS23645 Protein ID WP_015877380.1
Coordinates 1705376..1705873 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID C5AIF5
Locus tag NIW65_RS23650 Protein ID WP_015877381.1
Coordinates 1705870..1706151 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIW65_RS23610 1701397..1701492 - 96 Protein_1348 IS5/IS1182 family transposase -
NIW65_RS23615 1701564..1702109 - 546 Protein_1349 IS3 family transposase -
NIW65_RS23620 1702302..1703107 + 806 WP_085962370.1 IS5 family transposase -
NIW65_RS23625 1703073..1703384 - 312 WP_015877377.1 hypothetical protein -
NIW65_RS23630 1703401..1703652 - 252 WP_230674552.1 hypothetical protein -
NIW65_RS23635 1703779..1704384 - 606 Protein_1353 RHS repeat-associated core domain-containing protein -
NIW65_RS23640 1704798..1705295 - 498 WP_015877379.1 ProQ/FINO family protein -
NIW65_RS23645 1705376..1705873 - 498 WP_015877380.1 GNAT family N-acetyltransferase Toxin
NIW65_RS23650 1705870..1706151 - 282 WP_015877381.1 DUF1778 domain-containing protein Antitoxin
NIW65_RS23655 1706148..1706525 - 378 WP_173941242.1 hypothetical protein -
NIW65_RS23660 1706608..1706970 - 363 WP_017432434.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1701540..1702082 542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(5-91)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17544.11 Da        Isoelectric Point: 9.6894

>T250296 WP_015877380.1 NZ_CP100175:c1705873-1705376 [Burkholderia glumae]
VTGWRAPEPLSDAHGLDDFDSGVASLDTWLKRRALANQRSGASRTFVATRDGRVGAYYALASGAVTLEVAPGRFRRNMPD
PIPVVVLGRLAVDRAHQGIGVGRALVRDAGLRVLHAAAAIGIRGLIVHALSDSAKAFYERVGFEASPLDPMLLLITLADL
EHALS

Download         Length: 498 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10256.52 Da        Isoelectric Point: 5.0477

>AT250296 WP_015877381.1 NZ_CP100175:c1706151-1705870 [Burkholderia glumae]
MTSTTPRDTLNLRIRPDDRSLIDRAAAAAHKTRTDFVLDAARAAAEQTLLDQVVLSAEPQAYAAFLARLDEPVQPNEALR
QTMQTRAPWDPAA

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9HNC8

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9HNC9

References