Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 122811..123449 Replicon plasmid p49s4p
Accession NZ_CP100161
Organism Burkholderia glumae strain BGR49S

Toxin (Protein)


Gene name vapC Uniprot ID C5AP38
Locus tag NIW54_RS33160 Protein ID WP_012735347.1
Coordinates 122811..123212 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag NIW54_RS33165 Protein ID WP_257765493.1
Coordinates 123222..123449 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIW54_RS33130 119274..119543 + 270 WP_012735343.1 hypothetical protein -
NIW54_RS33135 119703..120317 + 615 Protein_110 error-prone DNA polymerase -
NIW54_RS33140 120333..120620 + 288 WP_012735344.1 hypothetical protein -
NIW54_RS33145 121725..121919 - 195 WP_124837731.1 hypothetical protein -
NIW54_RS33150 121974..122216 - 243 WP_012735345.1 hypothetical protein -
NIW54_RS33155 122234..122446 - 213 WP_257765492.1 hypothetical protein -
NIW54_RS33160 122811..123212 - 402 WP_012735347.1 type II toxin-antitoxin system VapC family toxin Toxin
NIW54_RS33165 123222..123449 - 228 WP_257765493.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NIW54_RS33170 123785..124474 - 690 WP_257739423.1 hypothetical protein -
NIW54_RS33175 124561..126388 - 1828 Protein_118 site-specific integrase -
NIW54_RS33180 126385..126765 - 381 WP_080569442.1 hypothetical protein -
NIW54_RS33185 126768..127085 - 318 WP_050811486.1 hypothetical protein -
NIW54_RS33190 127136..128224 - 1089 Protein_121 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..128913 128913


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-117)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14847.12 Da        Isoelectric Point: 5.2138

>T250287 WP_012735347.1 NZ_CP100161:c123212-122811 [Burkholderia glumae]
MPRFMLDTNMCIYLMKNQPEQVAKRFAECFVGDVVMSAITYAELEYGVAVSDNRAKERRNLAALIEDILVAPFDAAAAVA
YGPIREATRERKKDHLDKLIAAHAVALDVVLVTNNAKDFASYPGIKLDNWLND

Download         Length: 402 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8610.69 Da        Isoelectric Point: 6.3494

>AT250287 WP_257765493.1 NZ_CP100161:c123449-123222 [Burkholderia glumae]
MQTTRVFRNGNSQAVRIPADLAYERSDVELEIERVGDEIRIRPARRPLTGVLKKFAKFSQDFMAEGRGEQEQAET

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C5AP38

Antitoxin

Source ID Structure

References