Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1694022..1694797 Replicon chromosome
Accession NZ_CP100157
Organism Burkholderia glumae strain BGR49S

Toxin (Protein)


Gene name TacT2 Uniprot ID C5AIF4
Locus tag NIW54_RS25250 Protein ID WP_015877380.1
Coordinates 1694022..1694519 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID C5AIF5
Locus tag NIW54_RS25255 Protein ID WP_015877381.1
Coordinates 1694516..1694797 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIW54_RS25215 1690043..1690138 - 96 Protein_1332 IS5/IS1182 family transposase -
NIW54_RS25220 1690210..1690755 - 546 Protein_1333 IS3 family transposase -
NIW54_RS25225 1690948..1691753 + 806 WP_085962370.1 IS5 family transposase -
NIW54_RS25230 1691719..1692030 - 312 WP_015877377.1 hypothetical protein -
NIW54_RS25235 1692047..1692349 - 303 WP_255220127.1 DUF2380 domain-containing protein -
NIW54_RS25240 1692425..1693030 - 606 Protein_1337 RHS repeat-associated core domain-containing protein -
NIW54_RS25245 1693444..1693941 - 498 WP_015877379.1 ProQ/FINO family protein -
NIW54_RS25250 1694022..1694519 - 498 WP_015877380.1 GNAT family N-acetyltransferase Toxin
NIW54_RS25255 1694516..1694797 - 282 WP_015877381.1 DUF1778 domain-containing protein Antitoxin
NIW54_RS25260 1694794..1695171 - 378 WP_173941242.1 hypothetical protein -
NIW54_RS25265 1695254..1695616 - 363 WP_017432434.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fliC 1678029..1720344 42315
- flank IS/Tn - - 1690186..1690728 542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(5-91)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17544.11 Da        Isoelectric Point: 9.6894

>T250284 WP_015877380.1 NZ_CP100157:c1694519-1694022 [Burkholderia glumae]
VTGWRAPEPLSDAHGLDDFDSGVASLDTWLKRRALANQRSGASRTFVATRDGRVGAYYALASGAVTLEVAPGRFRRNMPD
PIPVVVLGRLAVDRAHQGIGVGRALVRDAGLRVLHAAAAIGIRGLIVHALSDSAKAFYERVGFEASPLDPMLLLITLADL
EHALS

Download         Length: 498 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10256.52 Da        Isoelectric Point: 5.0477

>AT250284 WP_015877381.1 NZ_CP100157:c1694797-1694516 [Burkholderia glumae]
MTSTTPRDTLNLRIRPDDRSLIDRAAAAAHKTRTDFVLDAARAAAEQTLLDQVVLSAEPQAYAAFLARLDEPVQPNEALR
QTMQTRAPWDPAA

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9HNC8

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9HNC9

References