Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 11257..11852 Replicon plasmid p33s1p
Accession NZ_CP100142
Organism Burkholderia glumae strain BGR33S

Toxin (Protein)


Gene name chpB Uniprot ID C5AN78
Locus tag NIV89_RS29675 Protein ID WP_012734107.1
Coordinates 11502..11852 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID C5AN79
Locus tag NIV89_RS29670 Protein ID WP_012734108.1
Coordinates 11257..11508 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIV89_RS29635 6526..6714 + 189 WP_017432455.1 hypothetical protein -
NIV89_RS29640 7466..7750 + 285 WP_017432347.1 hypothetical protein -
NIV89_RS29645 7764..8006 + 243 WP_124837682.1 hypothetical protein -
NIV89_RS29650 8003..8248 + 246 WP_127913916.1 hypothetical protein -
NIV89_RS29655 8305..8646 + 342 WP_012732710.1 hypothetical protein -
NIV89_RS29660 8649..10484 + 1836 WP_012732711.1 site-specific integrase -
NIV89_RS29665 10587..10994 + 408 WP_230674618.1 hypothetical protein -
NIV89_RS29670 11257..11508 + 252 WP_012734108.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NIV89_RS29675 11502..11852 + 351 WP_012734107.1 type II toxin-antitoxin system ChpB family toxin Toxin
NIV89_RS29680 11911..12105 + 195 WP_124837685.1 hypothetical protein -
NIV89_RS29685 12255..12476 + 222 WP_017433768.1 hypothetical protein -
NIV89_RS29690 12699..13163 + 465 WP_012734106.1 Lrp/AsnC family transcriptional regulator -
NIV89_RS29695 13477..15852 + 2376 WP_232252305.1 TonB-dependent receptor -
NIV89_RS29700 15884..16630 + 747 WP_232252306.1 energy transducer TonB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..145028 145028


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12389.37 Da        Isoelectric Point: 8.8909

>T250274 WP_012734107.1 NZ_CP100142:11502-11852 [Burkholderia glumae]
MVKRVKFERGDIVRVSLSPTVGREQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARFAGFAVPLSGSGTETQGVALV
NMVRMLDLEGRGARKIERAPVEVVEDALARLQTIIE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 8940.31 Da        Isoelectric Point: 6.2420

>AT250274 WP_012734108.1 NZ_CP100142:11257-11508 [Burkholderia glumae]
MELKIQKWGNSAAVRLPSVLLEQINASVGGSLNADVRPDGVLLTPARRKYALDDLVAQCDTKAPVPADMAAWGEIKPVGR
EAW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A246MF70

Antitoxin

Source ID Structure
AlphaFold DB A0A246MFN5

References