Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1699394..1700169 Replicon chromosome
Accession NZ_CP100141
Organism Burkholderia glumae strain BGR33S

Toxin (Protein)


Gene name TacT2 Uniprot ID C5AIF4
Locus tag NIV89_RS24645 Protein ID WP_015877380.1
Coordinates 1699394..1699891 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID C5AIF5
Locus tag NIV89_RS24650 Protein ID WP_015877381.1
Coordinates 1699888..1700169 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIV89_RS24610 1695415..1695510 - 96 Protein_1340 IS5/IS1182 family transposase -
NIV89_RS24615 1695582..1696127 - 546 Protein_1341 IS3 family transposase -
NIV89_RS24620 1696320..1697125 + 806 WP_085962370.1 IS5 family transposase -
NIV89_RS24625 1697091..1697402 - 312 WP_015877377.1 hypothetical protein -
NIV89_RS24630 1697419..1697721 - 303 WP_255220127.1 DUF2380 domain-containing protein -
NIV89_RS24635 1697797..1698402 - 606 Protein_1345 RHS repeat-associated core domain-containing protein -
NIV89_RS24640 1698816..1699313 - 498 WP_015877379.1 ProQ/FINO family protein -
NIV89_RS24645 1699394..1699891 - 498 WP_015877380.1 GNAT family N-acetyltransferase Toxin
NIV89_RS24650 1699888..1700169 - 282 WP_015877381.1 DUF1778 domain-containing protein Antitoxin
NIV89_RS24655 1700166..1700543 - 378 WP_173941242.1 hypothetical protein -
NIV89_RS24660 1700626..1700988 - 363 WP_017432434.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fliC 1685284..1720094 34810
- flank IS/Tn - - 1695558..1696100 542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(5-91)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17544.11 Da        Isoelectric Point: 9.6894

>T250272 WP_015877380.1 NZ_CP100141:c1699891-1699394 [Burkholderia glumae]
VTGWRAPEPLSDAHGLDDFDSGVASLDTWLKRRALANQRSGASRTFVATRDGRVGAYYALASGAVTLEVAPGRFRRNMPD
PIPVVVLGRLAVDRAHQGIGVGRALVRDAGLRVLHAAAAIGIRGLIVHALSDSAKAFYERVGFEASPLDPMLLLITLADL
EHALS

Download         Length: 498 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10256.52 Da        Isoelectric Point: 5.0477

>AT250272 WP_015877381.1 NZ_CP100141:c1700169-1699888 [Burkholderia glumae]
MTSTTPRDTLNLRIRPDDRSLIDRAAAAAHKTRTDFVLDAARAAAEQTLLDQVVLSAEPQAYAAFLARLDEPVQPNEALR
QTMQTRAPWDPAA

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9HNC8

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9HNC9

References