Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 12017..12612 Replicon plasmid p932p
Accession NZ_CP100139
Organism Burkholderia glumae strain R93

Toxin (Protein)


Gene name chpB Uniprot ID C5AN78
Locus tag NIV78_RS30000 Protein ID WP_012734107.1
Coordinates 12262..12612 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID C5AN79
Locus tag NIV78_RS29995 Protein ID WP_012734108.1
Coordinates 12017..12268 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIV78_RS29960 7371..7790 - 420 WP_237657883.1 hypothetical protein -
NIV78_RS29965 7787..8440 - 654 WP_017923861.1 hypothetical protein -
NIV78_RS29970 8457..9665 - 1209 WP_257758135.1 YadA-like family protein -
NIV78_RS29975 9708..9761 - 54 Protein_8 hypothetical protein -
NIV78_RS29980 9829..10557 - 729 WP_252836676.1 IS6 family transposase -
NIV78_RS29985 10600..11244 + 645 WP_254220801.1 site-specific integrase -
NIV78_RS29990 11347..11754 + 408 WP_230674618.1 hypothetical protein -
NIV78_RS29995 12017..12268 + 252 WP_012734108.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NIV78_RS30000 12262..12612 + 351 WP_012734107.1 type II toxin-antitoxin system ChpB family toxin Toxin
NIV78_RS30005 12671..12865 + 195 WP_124837685.1 hypothetical protein -
NIV78_RS30010 13015..13236 + 222 WP_017433768.1 hypothetical protein -
NIV78_RS30015 13459..13923 + 465 WP_012734106.1 Lrp/AsnC family transcriptional regulator -
NIV78_RS30020 14225..16612 + 2388 WP_051071184.1 TonB-dependent receptor -
NIV78_RS30025 16644..17390 + 747 WP_232252306.1 energy transducer TonB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..170947 170947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12389.37 Da        Isoelectric Point: 8.8909

>T250269 WP_012734107.1 NZ_CP100139:12262-12612 [Burkholderia glumae]
MVKRVKFERGDIVRVSLSPTVGREQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARFAGFAVPLSGSGTETQGVALV
NMVRMLDLEGRGARKIERAPVEVVEDALARLQTIIE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 8940.31 Da        Isoelectric Point: 6.2420

>AT250269 WP_012734108.1 NZ_CP100139:12017-12268 [Burkholderia glumae]
MELKIQKWGNSAAVRLPSVLLEQINASVGGSLNADVRPDGVLLTPARRKYALDDLVAQCDTKAPVPADMAAWGEIKPVGR
EAW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A246MF70

Antitoxin

Source ID Structure
AlphaFold DB A0A246MFN5

References