Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1115057..1115832 Replicon chromosome
Accession NZ_CP100137
Organism Burkholderia glumae strain R93

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag NIV78_RS22250 Protein ID WP_017423245.1
Coordinates 1115335..1115832 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag NIV78_RS22245 Protein ID WP_017423246.1
Coordinates 1115057..1115338 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIV78_RS22215 1110653..1110814 - 162 Protein_1029 IS110 family transposase -
NIV78_RS22225 1111996..1112157 + 162 Protein_1031 integrase core domain-containing protein -
NIV78_RS22230 1112615..1113175 + 561 WP_124837867.1 type 1 fimbrial protein -
NIV78_RS22235 1113285..1113551 + 267 Protein_1033 fimbria/pilus periplasmic chaperone -
NIV78_RS22245 1115057..1115338 + 282 WP_017423246.1 DUF1778 domain-containing protein Antitoxin
NIV78_RS22250 1115335..1115832 + 498 WP_017423245.1 GNAT family N-acetyltransferase Toxin
NIV78_RS22255 1115913..1116410 + 498 WP_251107809.1 ProQ/FINO family protein -
NIV78_RS22260 1116826..1117431 + 606 Protein_1038 RHS repeat-associated core domain-containing protein -
NIV78_RS22265 1117567..1117809 + 243 WP_257757996.1 TIGR02269 family lipoprotein -
NIV78_RS22270 1117826..1118110 + 285 WP_153478924.1 hypothetical protein -
NIV78_RS22275 1118233..1118778 + 546 Protein_1041 IS3 family transposase -
NIV78_RS22280 1118850..1118945 + 96 Protein_1042 IS5/IS1182 family transposase -
NIV78_RS22285 1119031..1120380 - 1350 WP_017424540.1 allantoin permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fliC 1108835..1130463 21628
- inside IScluster/Tn - - 1113584..1118802 5218


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-84)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17606.19 Da        Isoelectric Point: 9.6894

>T250267 WP_017423245.1 NZ_CP100137:1115335-1115832 [Burkholderia glumae]
MTGWRAPEPLSDAHGLDDFDSGVASLDTWLKRRALANQRSGASRTFVATRDGRVGAYYALASGAVTLEVAPGRFRRNMPD
PIPVVVLGRLAVDRAHQGIGVGRALVRDAGLRVLHAAAAIGIRSLIVHALSDSAKAFYERVGFEASPLDPMLLLITLADL
EHALS

Download         Length: 498 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10082.37 Da        Isoelectric Point: 7.0104

>AT250267 WP_017423246.1 NZ_CP100137:1115057-1115338 [Burkholderia glumae]
MASTTPRDTLNLRIRPDDRSLIDRAAAAAHKTRTDFVLDAARAAAEQTLLDQVVLSAEPQAYAAFLARLDAPAQPNAALR
QTMQTRAPWDPAA

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References