Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicB(antitoxin) |
| Location | 842702..843377 | Replicon | chromosome |
| Accession | NZ_CP100137 | ||
| Organism | Burkholderia glumae strain R93 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | NIV78_RS21090 | Protein ID | WP_251119048.1 |
| Coordinates | 843192..843377 (-) | Length | 62 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | NIV78_RS21085 | Protein ID | WP_257757920.1 |
| Coordinates | 842702..843121 (-) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NIV78_RS21060 | 837849..838433 | + | 585 | WP_244133257.1 | hypothetical protein | - |
| NIV78_RS21065 | 838554..839288 | + | 735 | WP_257757917.1 | hypothetical protein | - |
| NIV78_RS21070 | 839294..840091 | - | 798 | WP_012732720.1 | IS21-like element helper ATPase IstB | - |
| NIV78_RS21075 | 840084..841589 | - | 1506 | WP_012732721.1 | IS21 family transposase | - |
| NIV78_RS21080 | 841724..842590 | + | 867 | WP_257757919.1 | P63C domain-containing protein | - |
| NIV78_RS21085 | 842702..843121 | - | 420 | WP_257757920.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| NIV78_RS21090 | 843192..843377 | - | 186 | WP_251119048.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| NIV78_RS21095 | 843543..844076 | - | 534 | WP_257757922.1 | helix-turn-helix transcriptional regulator | - |
| NIV78_RS21100 | 844170..844355 | + | 186 | WP_257757923.1 | Arc family DNA-binding protein | - |
| NIV78_RS21105 | 844376..844693 | + | 318 | WP_257757925.1 | hypothetical protein | - |
| NIV78_RS21110 | 844686..844964 | + | 279 | WP_257757926.1 | hypothetical protein | - |
| NIV78_RS21115 | 844957..845235 | + | 279 | WP_257757928.1 | hypothetical protein | - |
| NIV78_RS21120 | 845228..845890 | + | 663 | WP_257757930.1 | KilA-N domain-containing protein | - |
| NIV78_RS21125 | 845893..846462 | + | 570 | WP_257757932.1 | hypothetical protein | - |
| NIV78_RS21130 | 846459..846914 | + | 456 | WP_251119056.1 | hypothetical protein | - |
| NIV78_RS21135 | 847842..848324 | + | 483 | WP_251119057.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 796499..881845 | 85346 | |
| - | inside | Prophage | - | - | 796499..867925 | 71426 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 62 a.a. Molecular weight: 6934.04 Da Isoelectric Point: 10.7447
>T250266 WP_251119048.1 NZ_CP100137:c843377-843192 [Burkholderia glumae]
MKYSEFRKWLKKQGAEFEKHKSGSSHFRVTLNGKTTIFPDHGSKEIGTGLVEAIKKQLGIK
MKYSEFRKWLKKQGAEFEKHKSGSSHFRVTLNGKTTIFPDHGSKEIGTGLVEAIKKQLGIK
Download Length: 186 bp
Antitoxin
Download Length: 140 a.a. Molecular weight: 15012.52 Da Isoelectric Point: 5.7642
>AT250266 WP_257757920.1 NZ_CP100137:c843121-842702 [Burkholderia glumae]
MLSYPVTLTPDSNGTLLVTFPDVPEAISVGENVEDALAQGLDALEAAFEIYFNEKRLIPAPSQAAPGQHVVTLPVLVASK
VLLANEAIEQKVRKAELARRLKVAPVQVDRLFKFSHGSKIEMIEAALGVLGKRLEIKAV
MLSYPVTLTPDSNGTLLVTFPDVPEAISVGENVEDALAQGLDALEAAFEIYFNEKRLIPAPSQAAPGQHVVTLPVLVASK
VLLANEAIEQKVRKAELARRLKVAPVQVDRLFKFSHGSKIEMIEAALGVLGKRLEIKAV
Download Length: 420 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|