Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | slvAT/RES(toxin) |
| Location | 5408..6354 | Replicon | plasmid p85s2p |
| Accession | NZ_CP100134 | ||
| Organism | Burkholderia glumae strain BGR85S | ||
Toxin (Protein)
| Gene name | slvT | Uniprot ID | C5AN91 |
| Locus tag | NIH91_RS29930 | Protein ID | WP_012732709.1 |
| Coordinates | 5821..6354 (+) | Length | 178 a.a. |
Antitoxin (Protein)
| Gene name | slvA | Uniprot ID | C5AN90 |
| Locus tag | NIH91_RS29925 | Protein ID | WP_012732708.1 |
| Coordinates | 5408..5824 (+) | Length | 139 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NIH91_RS29900 | 627..1337 | + | 711 | WP_257744742.1 | AAA family ATPase | - |
| NIH91_RS29905 | 1340..2419 | + | 1080 | WP_012732706.1 | ParB N-terminal domain-containing protein | - |
| NIH91_RS29910 | 2756..4087 | + | 1332 | WP_012732707.1 | hypothetical protein | - |
| NIH91_RS29915 | 4209..4535 | + | 327 | WP_127913985.1 | hypothetical protein | - |
| NIH91_RS29920 | 5075..5260 | + | 186 | WP_017432454.1 | hypothetical protein | - |
| NIH91_RS29925 | 5408..5824 | + | 417 | WP_012732708.1 | DUF2384 domain-containing protein | Antitoxin |
| NIH91_RS29930 | 5821..6354 | + | 534 | WP_012732709.1 | RES family NAD+ phosphorylase | Toxin |
| NIH91_RS29935 | 6524..6712 | + | 189 | WP_017432455.1 | hypothetical protein | - |
| NIH91_RS29940 | 7464..7748 | + | 285 | WP_017432347.1 | hypothetical protein | - |
| NIH91_RS29945 | 7762..8004 | + | 243 | WP_124837682.1 | hypothetical protein | - |
| NIH91_RS29950 | 8001..8246 | + | 246 | WP_127913916.1 | hypothetical protein | - |
| NIH91_RS29955 | 8303..8644 | + | 342 | WP_012732710.1 | hypothetical protein | - |
| NIH91_RS29960 | 8647..10482 | + | 1836 | WP_012732711.1 | site-specific integrase | - |
| NIH91_RS29965 | 10585..10992 | + | 408 | WP_230674618.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | fliL | 1..128913 | 128913 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 178 a.a. Molecular weight: 19101.61 Da Isoelectric Point: 4.7118
>T250263 WP_012732709.1 NZ_CP100134:5821-6354 [Burkholderia glumae]
MILTPLQDITAYRMHVPKWAVAPTSGAGAAKAGGRANRIGTPALYLALEAATAVAEYQQLSPLLPPGTLVSYRVTATPVV
DFTGGYRVDLWPPLWESFFCDWRHDWFNARIEPPSWVLGDEAIASGAKGILFRSTQAAGGTNLVLFVDQLGEGDRVDVHD
PAGALPRDQASWVDSPE
MILTPLQDITAYRMHVPKWAVAPTSGAGAAKAGGRANRIGTPALYLALEAATAVAEYQQLSPLLPPGTLVSYRVTATPVV
DFTGGYRVDLWPPLWESFFCDWRHDWFNARIEPPSWVLGDEAIASGAKGILFRSTQAAGGTNLVLFVDQLGEGDRVDVHD
PAGALPRDQASWVDSPE
Download Length: 534 bp
Antitoxin
Download Length: 139 a.a. Molecular weight: 14709.55 Da Isoelectric Point: 6.4664
>AT250263 WP_012732708.1 NZ_CP100134:5408-5824 [Burkholderia glumae]
MSTLAAARAPAGGPALANFDAFLSALREPDTAAPVLSARRYVAALNIDLQTLADQAHVHRNTVARAPQSASVQQFLREAI
RVIRAATDLSGDVQRALFWYRNEPLAVFDYQTAETLVSAGRADDVVRYVASLEAGAAG
MSTLAAARAPAGGPALANFDAFLSALREPDTAAPVLSARRYVAALNIDLQTLADQAHVHRNTVARAPQSASVQQFLREAI
RVIRAATDLSGDVQRALFWYRNEPLAVFDYQTAETLVSAGRADDVVRYVASLEAGAAG
Download Length: 417 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J9GLU3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J9GLX3 |