Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1690919..1691694 Replicon chromosome
Accession NZ_CP100132
Organism Burkholderia glumae strain BGR85S

Toxin (Protein)


Gene name TacT2 Uniprot ID C5AIF4
Locus tag NIH91_RS24070 Protein ID WP_015877380.1
Coordinates 1690919..1691416 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID C5AIF5
Locus tag NIH91_RS24075 Protein ID WP_015877381.1
Coordinates 1691413..1691694 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIH91_RS24035 1686940..1687035 - 96 Protein_1327 IS5/IS1182 family transposase -
NIH91_RS24040 1687107..1687652 - 546 Protein_1328 IS3 family transposase -
NIH91_RS24045 1687845..1688650 + 806 WP_085962370.1 IS5 family transposase -
NIH91_RS24050 1688616..1688927 - 312 WP_015877377.1 hypothetical protein -
NIH91_RS24055 1688944..1689246 - 303 WP_255220127.1 DUF2380 domain-containing protein -
NIH91_RS24060 1689322..1689927 - 606 Protein_1332 RHS repeat-associated core domain-containing protein -
NIH91_RS24065 1690341..1690838 - 498 WP_015877379.1 ProQ/FINO family protein -
NIH91_RS24070 1690919..1691416 - 498 WP_015877380.1 GNAT family N-acetyltransferase Toxin
NIH91_RS24075 1691413..1691694 - 282 WP_015877381.1 DUF1778 domain-containing protein Antitoxin
NIH91_RS24080 1691691..1692068 - 378 WP_173941242.1 hypothetical protein -
NIH91_RS24085 1692151..1692513 - 363 WP_017432434.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1679432..1712892 33460
- flank IS/Tn - - 1687083..1687625 542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(5-91)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17544.11 Da        Isoelectric Point: 9.6894

>T250262 WP_015877380.1 NZ_CP100132:c1691416-1690919 [Burkholderia glumae]
VTGWRAPEPLSDAHGLDDFDSGVASLDTWLKRRALANQRSGASRTFVATRDGRVGAYYALASGAVTLEVAPGRFRRNMPD
PIPVVVLGRLAVDRAHQGIGVGRALVRDAGLRVLHAAAAIGIRGLIVHALSDSAKAFYERVGFEASPLDPMLLLITLADL
EHALS

Download         Length: 498 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10256.52 Da        Isoelectric Point: 5.0477

>AT250262 WP_015877381.1 NZ_CP100132:c1691694-1691413 [Burkholderia glumae]
MTSTTPRDTLNLRIRPDDRSLIDRAAAAAHKTRTDFVLDAARAAAEQTLLDQVVLSAEPQAYAAFLARLDEPVQPNEALR
QTMQTRAPWDPAA

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9HNC8

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9HNC9

References