Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4884227..4884743 Replicon chromosome
Accession NZ_CP100120
Organism Klebsiella pneumoniae strain GZKP13

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag NIK98_RS24000 Protein ID WP_004178374.1
Coordinates 4884227..4884511 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NIK98_RS24005 Protein ID WP_002886901.1
Coordinates 4884501..4884743 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIK98_RS23975 (4879711) 4879711..4879974 - 264 WP_020324507.1 PTS system, lactose/cellobiose-specific IIB subunit -
NIK98_RS23980 (4880104) 4880104..4880277 + 174 WP_032408826.1 hypothetical protein -
NIK98_RS23985 (4880280) 4880280..4881023 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NIK98_RS23990 (4881380) 4881380..4883518 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
NIK98_RS23995 (4883759) 4883759..4884223 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NIK98_RS24000 (4884227) 4884227..4884511 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIK98_RS24005 (4884501) 4884501..4884743 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NIK98_RS24010 (4884821) 4884821..4886731 - 1911 WP_004178373.1 PRD domain-containing protein -
NIK98_RS24015 (4886754) 4886754..4887908 - 1155 WP_004178372.1 lactonase family protein -
NIK98_RS24020 (4887975) 4887975..4888715 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T250247 WP_004178374.1 NZ_CP100120:c4884511-4884227 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT250247 WP_002886901.1 NZ_CP100120:c4884743-4884501 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References