Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2686293..2687881 Replicon chromosome
Accession NZ_CP100120
Organism Klebsiella pneumoniae strain GZKP13

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NIK98_RS13285 Protein ID WP_004179815.1
Coordinates 2686293..2687615 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NIK98_RS13290 Protein ID WP_004176198.1
Coordinates 2687615..2687881 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIK98_RS13270 (2681349) 2681349..2683850 + 2502 WP_114501720.1 fimbria/pilus outer membrane usher protein -
NIK98_RS13275 (2683838) 2683838..2684842 + 1005 WP_004179822.1 fimbrial protein -
NIK98_RS13280 (2684984) 2684984..2686276 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NIK98_RS13285 (2686293) 2686293..2687615 - 1323 WP_004179815.1 type II toxin-antitoxin system HipA family toxin Toxin
NIK98_RS13290 (2687615) 2687615..2687881 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NIK98_RS13295 (2688147) 2688147..2688473 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NIK98_RS13300 (2688470) 2688470..2688970 - 501 WP_004179811.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NIK98_RS13305 (2688948) 2688948..2690327 - 1380 WP_004179808.1 nucleobase:cation symporter-2 family protein -
NIK98_RS13310 (2690673) 2690673..2691827 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NIK98_RS13315 (2691808) 2691808..2692731 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T250243 WP_004179815.1 NZ_CP100120:c2687615-2686293 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT250243 WP_004176198.1 NZ_CP100120:c2687881-2687615 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References