Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 827478..828135 Replicon chromosome
Accession NZ_CP100120
Organism Klebsiella pneumoniae strain GZKP13

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NIK98_RS04130 Protein ID WP_002916310.1
Coordinates 827725..828135 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NIK98_RS04125 Protein ID WP_002916312.1
Coordinates 827478..827744 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIK98_RS04100 (822634) 822634..824067 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
NIK98_RS04105 (824186) 824186..824914 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NIK98_RS04110 (824964) 824964..825275 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NIK98_RS04115 (825439) 825439..826098 + 660 WP_002916317.1 hemolysin III family protein -
NIK98_RS04120 (826249) 826249..827232 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
NIK98_RS04125 (827478) 827478..827744 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NIK98_RS04130 (827725) 827725..828135 + 411 WP_002916310.1 protein YgfX Toxin
NIK98_RS04135 (828142) 828142..828663 - 522 WP_064159432.1 flavodoxin FldB -
NIK98_RS04140 (828764) 828764..829660 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NIK98_RS04145 (829683) 829683..830396 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NIK98_RS04150 (830402) 830402..832135 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T250238 WP_002916310.1 NZ_CP100120:827725-828135 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT250238 WP_002916312.1 NZ_CP100120:827478-827744 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References