250236

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 578..1052 Replicon plasmid pHSKP1-4
Accession NZ_CP100118
Organism Klebsiella pneumoniae strain HSKP1

Toxin (Protein)


Gene name pasB Uniprot ID A0A8J3DT22
Locus tag NIL09_RS27580 Protein ID WP_004197762.1
Coordinates 786..1052 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID S1EJF5
Locus tag NIL09_RS27575 Protein ID WP_000879771.1
Coordinates 578..802 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIL09_RS27570 287..415 - 129 WP_000523570.1 hypothetical protein -
NIL09_RS27575 (NIL09_27560) 578..802 + 225 WP_000879771.1 DUF6290 family protein Antitoxin
NIL09_RS27580 (NIL09_27565) 786..1052 + 267 WP_004197762.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIL09_RS27585 (NIL09_27570) 1122..1472 - 351 WP_004197756.1 hypothetical protein -
NIL09_RS27590 (NIL09_27575) 1538..2083 - 546 WP_023317533.1 hypothetical protein -
NIL09_RS27595 (NIL09_27580) 2109..2435 - 327 WP_050516389.1 hypothetical protein -
NIL09_RS27600 (NIL09_27585) 3591..3767 + 177 WP_004197757.1 hypothetical protein -
NIL09_RS27605 (NIL09_27590) 3757..4101 + 345 WP_062955149.1 MobC family plasmid mobilization relaxosome protein -
NIL09_RS27610 (NIL09_27595) 4310..4744 + 435 Protein_8 relaxase/mobilization nuclease domain-containing protein -
NIL09_RS27615 (NIL09_27600) 4779..5288 + 510 WP_032433972.1 MbeB family mobilization protein -
NIL09_RS27620 (NIL09_27605) 5295..5507 + 213 WP_021527181.1 MbeD family mobilization/exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..5596 5596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(4-45)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10342.96 Da        Isoelectric Point: 9.8727

>T250236 WP_004197762.1 NZ_CP100118:786-1052 [Klebsiella pneumoniae]
MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRVLCEIRDDELVILAATI
GHRREVYD

Download         Length: 267 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8369.28 Da        Isoelectric Point: 4.6533

>AT250236 WP_000879771.1 NZ_CP100118:578-802 [Klebsiella pneumoniae]
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1EJF5

References