Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 6593..7173 Replicon plasmid pHSKP1-3
Accession NZ_CP100117
Organism Klebsiella pneumoniae strain HSKP1

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag NIL09_RS27545 Protein ID WP_071177730.1
Coordinates 6859..7173 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag NIL09_RS27540 Protein ID WP_000093040.1
Coordinates 6593..6871 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIL09_RS27510 (NIL09_27500) 2653..2802 - 150 WP_032440454.1 colicin release lysis protein -
NIL09_RS27515 (NIL09_27505) 2887..3144 - 258 WP_032440455.1 colicin E3-like toxin immunity protein -
NIL09_RS27520 (NIL09_27510) 3154..4839 - 1686 WP_032440457.1 colicin-like bacteriocin tRNase domain-containing protein -
NIL09_RS27525 (NIL09_27515) 5166..5411 + 246 WP_032440458.1 hypothetical protein -
NIL09_RS27530 (NIL09_27520) 5685..6056 + 372 WP_001237044.1 cell envelope integrity protein TolA -
NIL09_RS27535 (NIL09_27525) 6053..6418 + 366 WP_072354022.1 TonB family protein -
NIL09_RS27540 (NIL09_27530) 6593..6871 + 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
NIL09_RS27545 (NIL09_27535) 6859..7173 + 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIL09_RS27550 (NIL09_27540) 7337..7765 + 429 WP_001140599.1 hypothetical protein -
NIL09_RS27555 (NIL09_27545) 7791..7970 + 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
NIL09_RS27560 (NIL09_27550) 7997..8527 - 531 WP_071177729.1 hypothetical protein -
NIL09_RS27565 (NIL09_27555) 8534..9265 - 732 WP_071177728.1 MobC family replication-relaxation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..10061 10061


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T250235 WP_071177730.1 NZ_CP100117:6859-7173 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT250235 WP_000093040.1 NZ_CP100117:6593-6871 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References