Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 87848..88491 Replicon plasmid pHSKP1-2
Accession NZ_CP100116
Organism Klebsiella pneumoniae strain HSKP1

Toxin (Protein)


Gene name vagD Uniprot ID V0UN72
Locus tag NIL09_RS27400 Protein ID WP_001034044.1
Coordinates 88075..88491 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B1P7N7
Locus tag NIL09_RS27395 Protein ID WP_001261286.1
Coordinates 87848..88078 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIL09_RS27380 (83019) 83019..83249 + 231 WP_001261278.1 type II toxin-antitoxin system VapB family antitoxin -
NIL09_RS27385 (83246) 83246..83662 + 417 WP_001034046.1 type II toxin-antitoxin system VapC family toxin -
NIL09_RS27390 (83707) 83707..87501 - 3795 WP_001144732.1 hypothetical protein -
NIL09_RS27395 (87848) 87848..88078 + 231 WP_001261286.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NIL09_RS27400 (88075) 88075..88491 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin Toxin
NIL09_RS27405 (88566) 88566..90131 + 1566 WP_001128474.1 AAA family ATPase -
NIL09_RS27410 (90116) 90116..91138 + 1023 WP_000361402.1 helicase UvrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid ant(3'')-Ia / qacE / cmlA1 / sitABCD iutA / iucD / iucC / iucB / iucA 1..110202 110202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15232.66 Da        Isoelectric Point: 6.8536

>T250234 WP_001034044.1 NZ_CP100116:88075-88491 [Klebsiella pneumoniae]
VNKIYMLDTNICSFIMREQPEALLKHLEQSVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAACAILVTNNVREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8747.86 Da        Isoelectric Point: 4.3775

>AT250234 WP_001261286.1 NZ_CP100116:87848-88078 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLELEKADPDFMTEREDVVSDEGRVNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CHW1

Antitoxin

Source ID Structure
AlphaFold DB A0A829CKZ6

References