Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vagCD/VapC-VagC |
Location | 7025..7668 | Replicon | plasmid pHSKP1-1 |
Accession | NZ_CP100115 | ||
Organism | Klebsiella pneumoniae strain HSKP1 |
Toxin (Protein)
Gene name | vagD | Uniprot ID | D8L2J9 |
Locus tag | NIL09_RS25915 | Protein ID | WP_001044770.1 |
Coordinates | 7252..7668 (+) | Length | 139 a.a. |
Antitoxin (Protein)
Gene name | vagC | Uniprot ID | D5KTK7 |
Locus tag | NIL09_RS25910 | Protein ID | WP_001261282.1 |
Coordinates | 7025..7255 (+) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NIL09_RS25870 (2174) | 2174..2476 | + | 303 | WP_004197636.1 | hypothetical protein | - |
NIL09_RS25875 (2988) | 2988..3782 | - | 795 | WP_004197635.1 | site-specific integrase | - |
NIL09_RS25880 (3980) | 3980..4996 | - | 1017 | WP_017899884.1 | hypothetical protein | - |
NIL09_RS25885 (5007) | 5007..5321 | - | 315 | WP_053389906.1 | hypothetical protein | - |
NIL09_RS25890 (5348) | 5348..5743 | - | 396 | WP_017899885.1 | hypothetical protein | - |
NIL09_RS25895 (5912) | 5912..6217 | - | 306 | WP_013023785.1 | type II toxin-antitoxin system toxin CcdB | - |
NIL09_RS25900 (6219) | 6219..6437 | - | 219 | WP_001568025.1 | type II toxin-antitoxin system antitoxin CcdA | - |
NIL09_RS25905 (6607) | 6607..7068 | - | 462 | WP_160880186.1 | hypothetical protein | - |
NIL09_RS25910 (7025) | 7025..7255 | + | 231 | WP_001261282.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
NIL09_RS25915 (7252) | 7252..7668 | + | 417 | WP_001044770.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
NIL09_RS25920 (7742) | 7742..9304 | + | 1563 | WP_004206609.1 | AAA family ATPase | - |
NIL09_RS25925 (9289) | 9289..10311 | + | 1023 | WP_000361404.1 | helicase UvrD | - |
NIL09_RS25930 (10567) | 10567..11264 | + | 698 | WP_223174630.1 | IS1 family transposase | - |
NIL09_RS25935 (11293) | 11293..11565 | + | 273 | Protein_15 | transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Mobilizable plasmid | blaKPC-2 / sul1 / qacE / aadA2 / dfrA12 / catA2 | - | 1..142065 | 142065 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15106.52 Da Isoelectric Point: 7.1084
>T250220 WP_001044770.1 NZ_CP100115:7252-7668 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR
Download Length: 417 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GYM2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GZG3 |