Detailed information of TA system TA025022

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2065879..2066780
• Replicon: chromosome
• Accession: NC_014837
• Organism: Pantoea sp. At-9b

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: PAT9B_RS09475
• Protein ID: WP_041525784.1
• Coordinates: 2065879..2066340 (-)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: E6W8D1
• Locus tag: PAT9B_RS09480
• Protein ID: WP_013509039.1
• Coordinates: 2066337..2066780 (-)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PAT9B_RS09455	2061000..2062187	+	1188	WP_013509034.1	cytochrome c biogenesis protein DipZ	-
PAT9B_RS09460	2062287..2063705	-	1419	WP_013509035.1	aldehyde dehydrogenase family protein	-
PAT9B_RS09465	2063814..2064707	+	894	WP_013509036.1	LysR family transcriptional regulator	-
PAT9B_RS09470	2064978..2065877	+	900	WP_013509037.1	diguanylate cyclase	-
PAT9B_RS09475	2065879..2066340	-	462	WP_041525784.1	RES family NAD+ phosphorylase	Toxin
PAT9B_RS09480	2066337..2066780	-	444	WP_013509039.1	DUF2384 domain-containing protein	Antitoxin
PAT9B_RS09485	2066838..2067854	-	1017	WP_013509040.1	lipoate--protein ligase A	-
PAT9B_RS09490	2068096..2069211	+	1116	WP_041525785.1	beta-propeller fold lactonase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-143)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (32-89)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 17101.51 Da
• Isoelectric Point: 5.1239

>T25022 WP_041525784.1 NC_014837:c2066340-2065879 [Pantoea sp. At-9b]
VKLYRMTKTRFLSSAWSGYGAREGGGRWNSIGVSMVYASETASLTMLETLIHLQSASILDFFTLLSIDVPDEMIQWIDAA
QLPQDWAAAQAPAALRQFGDFWIDSQASVALRVPSALSPVEFNYLLNPEHPQFTALVKNAVEIPFRFDARFAR

Nucleotide

• Length: 462 bp

>T25022 NC_014837:c2066340-2065879 [Pantoea sp. At-9b]
GTGAAGTTATACCGCATGACCAAAACCCGCTTTCTCAGTTCAGCCTGGAGCGGCTACGGTGCCAGGGAAGGTGGCGGGCG
CTGGAACAGCATCGGTGTCTCAATGGTTTACGCTTCCGAGACCGCCTCGCTTACCATGCTGGAAACCCTCATTCATCTGC
AAAGCGCCAGCATTCTCGATTTCTTCACGCTGTTAAGCATCGACGTCCCGGACGAGATGATCCAATGGATTGATGCTGCG
CAATTACCGCAGGACTGGGCCGCAGCGCAGGCACCCGCCGCGCTGCGCCAGTTTGGTGATTTTTGGATCGACAGCCAGGC
GTCAGTCGCATTACGCGTGCCCAGCGCGCTGTCTCCGGTAGAATTTAATTACCTGCTCAATCCGGAACATCCGCAATTTA
CGGCTCTGGTTAAAAATGCGGTAGAAATCCCCTTTCGTTTCGATGCGCGTTTTGCACGCTGA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16317.60 Da
• Isoelectric Point: 8.5889

>AT25022 WP_013509039.1 NC_014837:c2066780-2066337 [Pantoea sp. At-9b]
MKQFTLPATPAAPERLWQFAGLTSADGVQLMGQIDAGLDGSVASRIVSWARITQADLRHMTGIPGTTFTRGLKNRFTSEQ
SERLVRFIRVMDRAVELFEGDREKALQWLNEPARALGNQKPGDIVSSETGAYEVLKLITRLEHGVYS

Nucleotide

• Length: 444 bp

>AT25022 NC_014837:c2066780-2066337 [Pantoea sp. At-9b]
ATGAAACAATTCACACTCCCGGCCACCCCTGCCGCGCCCGAACGTTTGTGGCAGTTTGCCGGGCTAACCAGCGCAGATGG
CGTGCAGTTGATGGGCCAGATTGATGCGGGCCTCGACGGTTCCGTTGCCAGCCGCATCGTGTCATGGGCGCGAATAACGC
AGGCTGATCTGCGCCATATGACCGGCATTCCCGGTACCACCTTTACCCGTGGGCTAAAAAACCGTTTTACCTCGGAGCAA
AGCGAGCGCCTGGTACGCTTTATCCGCGTGATGGATCGCGCGGTGGAGTTGTTTGAAGGCGACCGGGAAAAAGCGCTGCA
ATGGTTGAATGAACCGGCGCGCGCCCTCGGGAATCAGAAACCGGGCGATATCGTCTCGTCTGAAACCGGCGCGTATGAAG
TACTGAAACTGATCACCCGCCTTGAGCATGGTGTCTATTCGTGA

Structures

Antitoxin

• AlphaFold DB: E6W8D1