Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | kacAT/DUF1778(antitoxin) |
Location | 4695860..4696670 | Replicon | chromosome |
Accession | NZ_CP100114 | ||
Organism | Klebsiella pneumoniae strain HSKP1 |
Toxin (Protein)
Gene name | KacT | Uniprot ID | A0A060VJ83 |
Locus tag | NIL09_RS22795 | Protein ID | WP_004178461.1 |
Coordinates | 4695860..4696393 (-) | Length | 178 a.a. |
Antitoxin (Protein)
Gene name | KacA | Uniprot ID | J2E9Q7 |
Locus tag | NIL09_RS22800 | Protein ID | WP_002887278.1 |
Coordinates | 4696404..4696670 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NIL09_RS22790 (4694691) | 4694691..4695812 | + | 1122 | WP_002887282.1 | cupin domain-containing protein | - |
NIL09_RS22795 (4695860) | 4695860..4696393 | - | 534 | WP_004178461.1 | type II toxin-antitoxin system toxin KacT | Toxin |
NIL09_RS22800 (4696404) | 4696404..4696670 | - | 267 | WP_002887278.1 | type II toxin-antitoxin system antitoxin KacA | Antitoxin |
NIL09_RS22805 (4696773) | 4696773..4698206 | - | 1434 | WP_004178459.1 | Cu(+)/Ag(+) sensor histidine kinase | - |
NIL09_RS22810 (4698196) | 4698196..4698879 | - | 684 | WP_002887273.1 | copper response regulator transcription factor CusR | - |
NIL09_RS22815 (4699051) | 4699051..4700436 | + | 1386 | WP_004178457.1 | efflux transporter outer membrane subunit | - |
NIL09_RS22820 (4700454) | 4700454..4700798 | + | 345 | WP_004197273.1 | cation efflux system protein CusF | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 178 a.a. Molecular weight: 19810.65 Da Isoelectric Point: 5.2614
>T250215 WP_004178461.1 NZ_CP100114:c4696393-4695860 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES
Download Length: 534 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A060VJ83 |
Antitoxin
Source | ID | Structure |
---|---|---|
PDB | 5ZGN | |
AlphaFold DB | A0A0H3GLZ1 |