Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2726139..2727727 Replicon chromosome
Accession NZ_CP100114
Organism Klebsiella pneumoniae strain HSKP1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NIL09_RS13315 Protein ID WP_004179815.1
Coordinates 2726139..2727461 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NIL09_RS13320 Protein ID WP_004176198.1
Coordinates 2727461..2727727 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIL09_RS13300 (2721195) 2721195..2723696 + 2502 WP_020323802.1 fimbria/pilus outer membrane usher protein -
NIL09_RS13305 (2723684) 2723684..2724688 + 1005 WP_004179822.1 fimbrial protein -
NIL09_RS13310 (2724830) 2724830..2726122 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NIL09_RS13315 (2726139) 2726139..2727461 - 1323 WP_004179815.1 type II toxin-antitoxin system HipA family toxin Toxin
NIL09_RS13320 (2727461) 2727461..2727727 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NIL09_RS13325 (2727993) 2727993..2728319 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NIL09_RS13330 (2728316) 2728316..2728816 - 501 WP_004179811.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NIL09_RS13335 (2728794) 2728794..2730173 - 1380 WP_094932908.1 nucleobase:cation symporter-2 family protein -
NIL09_RS13340 (2730519) 2730519..2731673 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NIL09_RS13345 (2731654) 2731654..2732577 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T250212 WP_004179815.1 NZ_CP100114:c2727461-2726139 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT250212 WP_004176198.1 NZ_CP100114:c2727727-2727461 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References