250207

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 855625..856282 Replicon chromosome
Accession NZ_CP100114
Organism Klebsiella pneumoniae strain HSKP1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NIL09_RS04265 Protein ID WP_002916310.1
Coordinates 855872..856282 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NIL09_RS04260 Protein ID WP_002916312.1
Coordinates 855625..855891 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIL09_RS04235 (850781) 850781..852214 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
NIL09_RS04240 (852333) 852333..853061 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NIL09_RS04245 (853111) 853111..853422 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NIL09_RS04250 (853586) 853586..854245 + 660 WP_002916317.1 hemolysin III family protein -
NIL09_RS04255 (854396) 854396..855379 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
NIL09_RS04260 (855625) 855625..855891 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NIL09_RS04265 (855872) 855872..856282 + 411 WP_002916310.1 protein YgfX Toxin
NIL09_RS04270 (856289) 856289..856810 - 522 WP_004144730.1 flavodoxin FldB -
NIL09_RS04275 (856911) 856911..857807 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NIL09_RS04280 (857830) 857830..858543 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NIL09_RS04285 (858549) 858549..860282 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T250207 WP_002916310.1 NZ_CP100114:855872-856282 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT250207 WP_002916312.1 NZ_CP100114:855625-855891 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References