Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 157174..157919 Replicon plasmid pHSKP104-1
Accession NZ_CP100111
Organism Klebsiella pneumoniae strain HSKP104

Toxin (Protein)


Gene name tacT Uniprot ID A0A331KSM6
Locus tag NIL12_RS27015 Protein ID WP_032408901.1
Coordinates 157428..157919 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag NIL12_RS27010 Protein ID WP_014386183.1
Coordinates 157174..157440 (+) Length 89 a.a.

Genomic Context


NIL12_RS27000NIL12_RS27010NIL12_RS27015NIL12_RS26960NIL12_RS26965NIL12_RS26970NIL12_RS26975NIL12_RS26980NIL12_RS26985NIL12_RS26990NIL12_RS26995NIL12_RS27005NIL12_RS27020NIL12_RS27025NIL12_RS27030NIL12_RS27035NIL12_RS27040
Location: 156090..156575 (486 bp)
Type: Others
Protein ID: WP_014386185.1
Location: 157174..157440 (267 bp)
Type: Antitoxin
Protein ID: WP_014386183.1
Location: 157428..157919 (492 bp)
Type: Toxin
Protein ID: WP_032408901.1
Location: 152726..153139 (414 bp)
Type: Others
Protein ID: WP_013023817.1
Location: 153140..153418 (279 bp)
Type: Others
Protein ID: WP_004152721.1
Location: 153408..153728 (321 bp)
Type: Others
Protein ID: WP_014386190.1
Location: 153809..154033 (225 bp)
Type: Others
Protein ID: WP_014386189.1
Location: 154044..154256 (213 bp)
Type: Others
Protein ID: WP_014386188.1
Location: 154318..154644 (327 bp)
Type: Others
Protein ID: WP_014386187.1
Location: 155281..155631 (351 bp)
Type: Others
Protein ID: WP_014386186.1
Location: 155628..155900 (273 bp)
Type: Others
Protein ID: WP_032408902.1
Location: 156819..156977 (159 bp)
Type: Others
Protein ID: WP_014386184.1
Location: 158360..158611 (252 bp)
Type: Others
Protein ID: WP_032408900.1
Location: 158808..160400 (1593 bp)
Type: Others
Protein ID: Protein_180
Location: 160431..160781 (351 bp)
Type: Others
Protein ID: WP_014386180.1
Location: 160778..161218 (441 bp)
Type: Others
Protein ID: WP_014386179.1
Location: 161480..162235 (756 bp)
Type: Others
Protein ID: WP_032408898.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NIL12_RS26960 (NIL12_26940)152726..153139-414WP_013023817.1helix-turn-helix domain-containing protein-
NIL12_RS26965 (NIL12_26945)153140..153418-279WP_004152721.1helix-turn-helix transcriptional regulator-
NIL12_RS26970 (NIL12_26950)153408..153728-321WP_014386190.1type II toxin-antitoxin system RelE/ParE family toxin-
NIL12_RS26975 (NIL12_26955)153809..154033-225WP_014386189.1hypothetical protein-
NIL12_RS26980 (NIL12_26960)154044..154256-213WP_014386188.1hypothetical protein-
NIL12_RS26985 (NIL12_26965)154318..154644-327WP_014386187.1hypothetical protein-
NIL12_RS26990 (NIL12_26970)155281..155631-351WP_014386186.1hypothetical protein-
NIL12_RS26995 (NIL12_26975)155628..155900-273WP_032408902.1hypothetical protein-
NIL12_RS27000 (NIL12_26980)156090..156575+486WP_014386185.1hypothetical protein-
NIL12_RS27005 (NIL12_26985)156819..156977-159WP_014386184.1type I toxin-antitoxin system Hok family toxin-
NIL12_RS27010 (NIL12_26990)157174..157440+267WP_014386183.1DUF1778 domain-containing proteinAntitoxin
NIL12_RS27015 (NIL12_26995)157428..157919+492WP_032408901.1GNAT family N-acetyltransferaseToxin
NIL12_RS27020 (NIL12_27000)158360..158611-252WP_032408900.1aldo/keto reductase-
NIL12_RS27025 (NIL12_27005)158808..160400-1593Protein_180IS66 family transposase-
NIL12_RS27030 (NIL12_27010)160431..160781-351WP_014386180.1IS66 family insertion sequence element accessory protein TnpB-
NIL12_RS27035 (NIL12_27015)160778..161218-441WP_014386179.1transposase-
NIL12_RS27040 (NIL12_27020)161480..162235-756WP_032408898.1DeoR/GlpR family DNA-binding transcription regulator-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideConjugative plasmidtet(A) / blaOXA-1 / aac(6')-Ib-cr / blaCTX-M-15 / blaTEM-1B / mph(A)-1..201929201929


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(89-149)

Antitoxin

(2-87)


Sequences


Toxin        


Download         Length: 164 a.a.        Molecular weight: 17667.46 Da        Isoelectric Point: 8.8757

>T250202 WP_032408901.1 NZ_CP100111:157428-157919 [Klebsiella pneumoniae]
VGKVTAPVPLGTSHILAEFHCGEPVLDEWIKHRGLKNQSLGAARTFVVCRGNASQVLAYYSLATGSVTHAIAPGSLRRNM
PDPVPVIILARLAVDTSYHGQGLGADLLHDAVLRCCRVAENIGVRAVMVHALSDSARQFYIHHGFIPSQTQDRTLFLRLP
LIT

Download         Length: 492 bp


Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.66 Da        Isoelectric Point: 5.1169

>AT250202 WP_014386183.1 NZ_CP100111:157174-157440 [Klebsiella pneumoniae]
MKSDVQLNIRAKEAQRALIDTAAEILHKSRTDFILEMACQAAENVILDRRMFNLNDEQYAEFIDMLDAPVTANPAMEKLL
ARKPQWAK

Download         Length: 267 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A331KSM6


Antitoxin

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Source
ID
Structure
No matching records found

References