Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1099424..1100044 Replicon chromosome
Accession NC_014837
Organism Pantoea sp. At-9b

Toxin (Protein)


Gene name Hha Uniprot ID E6W9D1
Locus tag PAT9B_RS04900 Protein ID WP_013508151.1
Coordinates 1099424..1099642 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID E6W9D2
Locus tag PAT9B_RS04905 Protein ID WP_013508152.1
Coordinates 1099667..1100044 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAT9B_RS04875 1095297..1095635 + 339 WP_007886947.1 P-II family nitrogen regulator -
PAT9B_RS04880 1095667..1096956 + 1290 WP_013508147.1 ammonium transporter AmtB -
PAT9B_RS04885 1097029..1097892 - 864 WP_013508148.1 acyl-CoA thioesterase II -
PAT9B_RS04890 1098098..1098655 + 558 WP_013508149.1 YbaY family lipoprotein -
PAT9B_RS04895 1098710..1099024 - 315 WP_013508150.1 MGMT family protein -
PAT9B_RS04900 1099424..1099642 - 219 WP_013508151.1 hemolysin expression modulator Hha Toxin
PAT9B_RS04905 1099667..1100044 - 378 WP_013508152.1 Hha toxicity modulator TomB Antitoxin
PAT9B_RS04910 1100191..1100544 - 354 WP_041525900.1 hypothetical protein -
PAT9B_RS04915 1100863..1101519 + 657 WP_013508154.1 ABC transporter ATP-binding protein -
PAT9B_RS04920 1101516..1102355 + 840 WP_013508155.1 metal ABC transporter permease -
PAT9B_RS04925 1102378..1103256 + 879 WP_013508156.1 metal ABC transporter substrate-binding protein -
PAT9B_RS04930 1103301..1103444 - 144 WP_013508157.1 type B 50S ribosomal protein L36 -
PAT9B_RS04935 1103456..1103716 - 261 WP_013508158.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8543.84 Da        Isoelectric Point: 8.9106

>T25020 WP_013508151.1 NC_014837:c1099642-1099424 [Pantoea sp. At-9b]
MSNQALTKTDYLMRLRRCRSIDTLERVIEKNKYELSDDELAVFYSAADHRLAELTMNKLYDKVPGSVWKFVR

Download         Length: 219 bp

>T25020 NC_014837:c1099642-1099424 [Pantoea sp. At-9b]
ATGAGCAATCAAGCCTTAACCAAAACCGATTATTTGATGCGACTGCGCCGCTGTCGCTCAATCGATACCCTTGAGCGGGT
GATTGAGAAAAACAAGTATGAATTGTCCGATGACGAGTTAGCGGTATTCTACTCTGCTGCCGATCACCGCCTTGCAGAGC
TGACGATGAATAAGCTCTACGATAAAGTGCCCGGTTCTGTCTGGAAGTTCGTCCGCTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14711.37 Da        Isoelectric Point: 4.4796

>AT25020 WP_013508152.1 NC_014837:c1100044-1099667 [Pantoea sp. At-9b]
MDEYSPKRHDIAQLKFLCENLFDESMATLTDSHHGWVNDPTSESNLQLNDLIEHIASFTMNYKIKHVEDTALITQIDEYL
DDTFMLFSSYGINTQDLQRWQRSARRLFNLFAEECAFLQQPSHSF

Download         Length: 378 bp

>AT25020 NC_014837:c1100044-1099667 [Pantoea sp. At-9b]
ATGGACGAATACTCACCGAAACGGCATGATATTGCCCAGCTTAAATTTCTGTGTGAGAACCTGTTTGACGAAAGTATGGC
AACCTTAACTGACAGTCATCATGGCTGGGTTAATGATCCTACCTCGGAAAGCAATTTACAGCTCAACGATTTGATTGAGC
ATATCGCGTCTTTCACGATGAATTACAAAATTAAGCATGTTGAAGATACAGCACTGATTACGCAAATCGATGAATATCTT
GACGATACCTTTATGCTGTTTAGCAGCTACGGAATCAATACTCAGGATCTTCAACGTTGGCAACGTTCAGCACGACGCTT
ATTTAACCTGTTTGCCGAAGAGTGCGCTTTTCTACAGCAACCCAGCCATTCCTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9NR78

Antitoxin

Source ID Structure
AlphaFold DB E6W9D2

References