Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4857433..4857949 Replicon chromosome
Accession NZ_CP100110
Organism Klebsiella pneumoniae strain HSKP104

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag NIL12_RS23530 Protein ID WP_004178374.1
Coordinates 4857433..4857717 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NIL12_RS23535 Protein ID WP_002886901.1
Coordinates 4857707..4857949 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIL12_RS23505 (4852917) 4852917..4853180 - 264 WP_020324507.1 PTS system, lactose/cellobiose-specific IIB subunit -
NIL12_RS23510 (4853310) 4853310..4853483 + 174 WP_032408826.1 hypothetical protein -
NIL12_RS23515 (4853486) 4853486..4854229 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NIL12_RS23520 (4854586) 4854586..4856724 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
NIL12_RS23525 (4856965) 4856965..4857429 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NIL12_RS23530 (4857433) 4857433..4857717 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIL12_RS23535 (4857707) 4857707..4857949 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NIL12_RS23540 (4858027) 4858027..4859937 - 1911 WP_004178373.1 PRD domain-containing protein -
NIL12_RS23545 (4859960) 4859960..4861114 - 1155 WP_004178372.1 lactonase family protein -
NIL12_RS23550 (4861181) 4861181..4861921 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T250198 WP_004178374.1 NZ_CP100110:c4857717-4857433 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT250198 WP_002886901.1 NZ_CP100110:c4857949-4857707 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References